A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was
facilitated by the European Respiratory Society (ERS) and the International Society for …

By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality.
Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco …

… overlay panel Elisabeth Diot MD a , Eric Boissinot MD b , Elisabeth Asquier MD c , Jean-Louis
Guilmot MD a , Etienne Lemarié MD b , Chantal Valat PharmD d , Patrice Diot MD, PhD b …

Using an in vitro model, we compared efficiencies of jet nebulizers and metered-dose
inhalers (MDI) with actuator devices to deliver albuterol in various conditions of mechanical …

Introduction: The pulmonary route is not invasive and can be used to target drugs directly to
the lungs, limiting the exposure of secondary organs. It is, thus, an attractive alternative to the …

Uncontrolled proteolysis by neutrophil serine proteases (NSPs) in lung secretions is a hallmark
of cystic fibrosis (CF). We have shown that the active neutrophil elastase, protease 3, and …

Background: High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive
and emergency care departments. Patients suffering from respiratory failure, who are likely …

Monoclonal antibodies (mAbs) are usually delivered systemically, but only a small proportion
of the drug reaches the lung after intravenous injection. The inhalation route is an attractive …

Lung deposition of inhaled drugs in ventilated neonates has been studied in models of
questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to …

Aerosol drug delivery permits the development of dose-intensification strategies in severe,
malignant lung diseases. The aim of the study was to demonstrate that the encapsulation of …