We introduce and validate a new precision oncology framework for the systematic
prioritization of drugs targeting mechanistic tumor dependencies in individual patients …

Abstract BACKGROUND African‐American (AA) women are more likely to be diagnosed
with an advanced stage of breast carcinoma than are white women. After adjustment for …

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

Background: Abnormal expression of the cell cycle regulatory proteins p27 Kip1 (p27) and
cyclin E may be associated with breast cancer survival and relapse. We studied these …

Combined estrogen and progestin hormone therapy (CHT) increases breast cancer risk, but
this risk varies by breast cancer type. Several studies indicate that CHT is more strongly …

Gene expression signatures are commonly used as predictive biomarkers, but do not
capture structural features within the tissue architecture. Here we apply a 2-step machine …

Introduction UDP-glucuronosyltransferase (UGT) and sulfotransferase (SULT) enzymes are
involved in removing sex hormones from circulation. Polymorphic variation in five UGT and …

Objective Universal screening of endometrial carcinoma (EC) for mismatch repair deficiency
(MMRd) and Lynch syndrome uses presence of MLH1 methylation to omit common sporadic …

The limited clinical success of anti‐HGF/MET drugs can be attributed to the lack of predictive
biomarkers that adequately select patients for treatment. We demonstrate here that …

Pancreatic ductal adenocarcinoma (PDAC) is highly metastatic and represents one of the
deadliest forms of human cancers. Previous studies showed that activation of Yes …