Antioxidants as therapeutic agents for liver disease

AK Singal, SC Jampana, SA Weinman - Liver International, 2011 - Wiley Online Library
Oxidative stress is commonly associated with a number of liver diseases and is thought to
play a role in the pathogenesis of chronic hepatitis C, alcoholic liver disease, non‐alcoholic …

Forkhead box class O transcription factors in liver function and disease

I Tikhanovich, J Cox… - Journal of gastroenterology …, 2013 - Wiley Online Library
The forkhead box transcription factor class O (FOXO) family represents a group of
transcription factors that is required for a number of stress‐related transcriptional programs …

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

M Okuda, K Li, MR Beard, LA Showalter, F Scholle… - Gastroenterology, 2002 - Elsevier
Background & Aims: The mechanisms of liver injury in chronic hepatitis C virus (HCV)
infection are poorly understood. Indirect evidence suggests that oxidative stress and …

Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection

YM Loo, DM Owen, K Li, AK Erickson… - Proceedings of the …, 2006 - National Acad Sciences
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN
promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-α/β …

[HTML][HTML] Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production

M Korenaga, T Wang, Y Li, LA Showalter… - Journal of Biological …, 2005 - ASBMB
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to
fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the …

Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus

H Lerat, M Honda, MR Beard, K Loesch, J Sun, Y Yang… - Gastroenterology, 2002 - Elsevier
Background & Aims: The aim of this study was to determine whether expression of hepatitis
C virus proteins alters hepatic morphology or function in the absence of inflammation …

Alcohol and hepatitis C virus–interactions in immune dysfunctions and liver damage

G Szabo, JR Wands, A Eken, NA Osna… - Alcoholism: Clinical …, 2010 - Wiley Online Library
Hepatitis C virus infection affects 170 million people worldwide, and the majority of
individuals exposed to HCV develop chronic hepatitis leading to progressive liver damage …

[HTML][HTML] Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production

AL Wozniak, S Griffin, D Rowlands, M Harris… - PLoS …, 2010 - journals.plos.org
The hepatitis C virus (HCV) p7 protein is critical for virus production and an attractive
antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel …

[HTML][HTML] The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

AL Wozniak, A Adams, KE King, W Dunn… - Journal of Cell …, 2020 - rupress.org
Cells respond to inflammatory disease states by releasing exosomes containing highly
specific protein and RNA cargos, but how inflammation alters cargo specificity and secretion …

Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity

Y Li, DF Boehning, T Qian, VL Popov… - The FASEB …, 2007 - Wiley Online Library
Many viruses have evolved mechanisms to alter mitochondrial function. The hepatitis C virus
(HCV) produces a viral core protein that targets to mitochondria and increases Ca2+ …