Defects in the adherens junction complex (E-cadherin/β-catenin) in inflammatory bowel disease

S Mehta, A Nijhuis, T Kumagai, J Lindsay… - Cell and tissue …, 2015 - Springer
The epithelial monolayer of the intestine is a selective barrier permitting nutrient and
electrolyte absorption yet acting to protect the underlying tissue compartments and cellular …

Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD

NA Kennedy, S Lin, JR Goodhand, N Chanchlani… - Gut, 2021 - gut.bmj.com
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a
lower level of immunity across more of the population. We investigated whether patients with …

[HTML][HTML] Enteral nutrition in adult Crohn's disease: toward a paradigm shift

S Di Caro, KC Fragkos, K Keetarut, HF Koo… - Nutrients, 2019 - mdpi.com
Medical and surgical treatments for Crohn's disease are associated with toxic effects.
Medical therapy aims for mucosal healing and is achievable with biologics …

Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab

NA Kennedy, JR Goodhand, C Bewshea, R Nice… - Gut, 2021 - gut.bmj.com
Objective Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following
pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious …

[HTML][HTML] Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn's …

SA Taylor, S Mallett, G Bhatnagar… - The lancet …, 2018 - thelancet.com
Background Magnetic resonance enterography (MRE) and ultrasound are used to image
Crohn's disease, but their comparative accuracy for assessing disease extent and activity is …

Home parenteral nutrition in patients with advanced cancer: a systematic review and meta-analysis

FJ O'Hanlon, KC Fragkos, L Fini, PS Patel… - Nutrition and …, 2021 - Taylor & Francis
The use of home parenteral nutrition (HPN) in patients with incurable cancer remains
controversial with significant variation worldwide. We aimed to systematically evaluate the …

[HTML][HTML] Nutritional status and COVID-19: an opportunity for lasting change?

S Mehta - Clinical Medicine, 2020 - ncbi.nlm.nih.gov
The coronavirus disease of 2019 (COVID-19) pandemic has placed many healthcare
systems, including the NHS, under unprecedented pressure. Mortality appears to be highest …

Low serum levels of microRNA-19 are associated with a stricturing Crohn's disease phenotype

A Lewis, S Mehta, LN Hanna… - Inflammatory Bowel …, 2015 - academic.oup.com
Background Development of fibrosis and subsequent stricture formation in Crohn's disease
(CD) increases morbidity and rates of surgery and reduces patients' quality of life. There are …

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational …

S Sebastian, GJ Walker, NA Kennedy… - The Lancet …, 2021 - thelancet.com
Background There is a paucity of evidence to support safe and effective management of
patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to …

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

A Lewis, S Sánchez, G Berti, B Pan-Castillo… - Clinical …, 2022 - portlandpress.com
Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease
(CD), linked to increased morbidity and costs. The present study investigates the …