MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Non-coding RNA species contribute more than 90% of all transcripts and have gained
increasing attention in the last decade. One of the most recent members of this group are …

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of
biological activities, including mechanosensation, osmotic homeostasis, and cell signaling …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

Autosomal-dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause
of end-stage renal disease in adults. Affected individuals and families face a significant …

Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …

Regulatory T cells (Treg cells) are essential for self-tolerance and immune homeostasis.
Lack of effector T cell (Teff cell) function and gain of suppressive activity by Treg cells are …

Cilia are specialized organelles that play an important role in several biological processes,
including mechanosensation, photoperception, and osmosignaling. Mutations in proteins …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …