The contribution of tumorigenic stem cells to haematopoietic cancers has been established
for some time, and cells possessing stem-cell properties have been described in several …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Abstract PTEN/MMAC1 (phosphatase, tensin homologue/mutated in multiple advanced
cancers) is a tumor suppressor protein that has sequence homology with dual-specificity …

Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL)
disease tumor suppressor gene. A restriction fragment encompassing the gene showed …

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4+ T
lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 …

Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited
kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal …

We report the sequence and analysis of the 814-megabase genome of the sea urchin
Strongylocentrotus purpuratus, a model for developmental and systems biology. The …

The nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder
characterized by multiple basal cell carcinomas (BCCs), pits of the palms and soles, jaw …