Background Clostridium difficile infection is a serious diarrheal illness associated with
substantial morbidity and mortality. Patients generally have a response to oral vancomycin …

Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro
and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We …

Importance Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients
with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate …

Background Cytomegalovirus (CMV) infection remains a common complication after
allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the …

Background Mucormycosis is an uncommon invasive fungal disease with high mortality and
few treatment options. Isavuconazole is a triazole active in vitro and in animal models …

The incidence of Clostridium difficile infection (CDI) has risen 400% in the last decade. It
currently ranks as the third most common nosocomial infection. CDI has now crossed over …

Background The use of available antiviral agents for the prevention of cytomegalovirus
(CMV) disease is limited by frequent toxic effects and the emergence of resistance. CMX001 …

Background Cytomegalovirus (CMV) infection is a leading cause of illness and death in
patients who have undergone allogeneic hematopoietic-cell transplantation. Available …

Background. Treatment guidelines recommend stopping all implicated antibiotics at the
onset of Clostridium difficile infection (CDI), but many individuals have persistent or new …

Abstract Background. Managing recurrent Clostridium difficile infection (CDI) presents a
significant challenge for clinicians and patients. Fecal microbiota transplantation (FMT) is a …