[HTML][HTML] DNA extraction for human microbiome studies: the issue of standardization
Among the laboratory and bioinformatic processing steps for human microbiome studies, a
lack of consistency in DNA extraction methodologies is hindering the ability to compare …
lack of consistency in DNA extraction methodologies is hindering the ability to compare …
[HTML][HTML] Targeting dietary and microbial tryptophan-indole metabolism as therapeutic approaches to colon cancer
M Wyatt, KL Greathouse - Nutrients, 2021 - mdpi.com
Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of
tryptophan to indolic compounds are fundamental for host health; both of which are altered …
tryptophan to indolic compounds are fundamental for host health; both of which are altered …
[HTML][HTML] Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer
KL Greathouse, M Wyatt, AJ Johnson, EP Toy, JM Khan… - Neoplasia, 2022 - Elsevier
Dietary patterns contribute to cancer risk. Separately, microbial factors influence the
development of several cancers. However, the interaction of diet and the microbiome and …
development of several cancers. However, the interaction of diet and the microbiome and …
[HTML][HTML] Interaction between the microbiome and TP53 in human lung cancer
Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …
Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis
KL Greathouse, T Bredfeldt, JI Everitt, K Lin… - Molecular Cancer …, 2012 - AACR
Environmental exposures during sensitive windows of development can reprogram normal
physiologic responses and alter disease susceptibility later in life in a process known as …
physiologic responses and alter disease susceptibility later in life in a process known as …
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT
TG Bredfeldt, KL Greathouse, SH Safe… - Molecular …, 2010 - academic.oup.com
Although rapid, membrane-activated estrogen receptor (ER) signaling is no longer
controversial, the biological function of this nongenomic signaling is not fully characterized …
controversial, the biological function of this nongenomic signaling is not fully characterized …
[HTML][HTML] High-resolution profiling of the gut microbiome reveals the extent of Clostridium difficile burden
N Daquigan, AM Seekatz, KL Greathouse… - NPJ biofilms and …, 2017 - nature.com
Microbiome profiling through 16S rRNA gene sequence analysis has proven to be a useful
research tool in the study of C. difficile infection (CDI); however, CDI microbiome studies …
research tool in the study of C. difficile infection (CDI); however, CDI microbiome studies …
[HTML][HTML] Co-enrichment of cancer-associated bacterial taxa is correlated with immune cell infiltrates in esophageal tumor tissue
Esophageal carcinoma (ESCA) is a leading cause of cancer-related death worldwide, and
certain oral and intestinal pathogens have been associated with cancer development and …
certain oral and intestinal pathogens have been associated with cancer development and …
The intratumor microbiome is associated with microsatellite instability
Intratumoral microbes may have multifunctional roles in carcinogenesis. Microsatellite
instability (MSI) is associated with higher tumor immunity and mutational burden. Using …
instability (MSI) is associated with higher tumor immunity and mutational burden. Using …
Contribution of the microbiota and their secretory products to inflammation and colorectal cancer pathogenesis: the role of toll-like receptors
Alterations in diversity and function of the gut microbiome are associated with concomitant
changes in immune response, including chronic inflammation. Chronic inflammation is a …
changes in immune response, including chronic inflammation. Chronic inflammation is a …