[HTML][HTML] DNA extraction for human microbiome studies: the issue of standardization

KL Greathouse, R Sinha, E Vogtmann - Genome biology, 2019 - Springer
Among the laboratory and bioinformatic processing steps for human microbiome studies, a
lack of consistency in DNA extraction methodologies is hindering the ability to compare …

[HTML][HTML] Targeting dietary and microbial tryptophan-indole metabolism as therapeutic approaches to colon cancer

M Wyatt, KL Greathouse - Nutrients, 2021 - mdpi.com
Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of
tryptophan to indolic compounds are fundamental for host health; both of which are altered …

[HTML][HTML] Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer

KL Greathouse, M Wyatt, AJ Johnson, EP Toy, JM Khan… - Neoplasia, 2022 - Elsevier
Dietary patterns contribute to cancer risk. Separately, microbial factors influence the
development of several cancers. However, the interaction of diet and the microbiome and …

[HTML][HTML] Interaction between the microbiome and TP53 in human lung cancer

KL Greathouse, JR White, AJ Vargas, VV Bliskovsky… - Genome biology, 2018 - Springer
Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …

Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis

KL Greathouse, T Bredfeldt, JI Everitt, K Lin… - Molecular Cancer …, 2012 - AACR
Environmental exposures during sensitive windows of development can reprogram normal
physiologic responses and alter disease susceptibility later in life in a process known as …

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT

TG Bredfeldt, KL Greathouse, SH Safe… - Molecular …, 2010 - academic.oup.com
Although rapid, membrane-activated estrogen receptor (ER) signaling is no longer
controversial, the biological function of this nongenomic signaling is not fully characterized …

[HTML][HTML] High-resolution profiling of the gut microbiome reveals the extent of Clostridium difficile burden

N Daquigan, AM Seekatz, KL Greathouse… - NPJ biofilms and …, 2017 - nature.com
Microbiome profiling through 16S rRNA gene sequence analysis has proven to be a useful
research tool in the study of C. difficile infection (CDI); however, CDI microbiome studies …

[HTML][HTML] Co-enrichment of cancer-associated bacterial taxa is correlated with immune cell infiltrates in esophageal tumor tissue

KL Greathouse, JK Stone, AJ Vargas, A Choudhury… - Scientific Reports, 2024 - nature.com
Esophageal carcinoma (ESCA) is a leading cause of cancer-related death worldwide, and
certain oral and intestinal pathogens have been associated with cancer development and …

The intratumor microbiome is associated with microsatellite instability

DA Byrd, W Fan, KL Greathouse, MC Wu… - JNCI: Journal of the …, 2023 - academic.oup.com
Intratumoral microbes may have multifunctional roles in carcinogenesis. Microsatellite
instability (MSI) is associated with higher tumor immunity and mutational burden. Using …

Contribution of the microbiota and their secretory products to inflammation and colorectal cancer pathogenesis: the role of toll-like receptors

A Sheikh, J Taube, KL Greathouse - Carcinogenesis, 2021 - academic.oup.com
Alterations in diversity and function of the gut microbiome are associated with concomitant
changes in immune response, including chronic inflammation. Chronic inflammation is a …