User profiles for "author:Julian R F Walters"

Julian RF Walters

Imperial College London
Verified email at imperial.ac.uk
Cited by 11230

Managing bile acid diarrhoea

JRF Walters, SS Pattni - Therapeutic advances in …, 2010 - journals.sagepub.com
Bowel symptoms including diarrhoea can be produced when excess bile acids (BA) are
present in the colon. This condition, known as bile acid or bile salt malabsorption, has been …

Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer

M Raman, AN Milestone, JRF Walters… - Therapeutic …, 2011 - journals.sagepub.com
Over the past 5 years, there has been a rapid resurgence of interest in vitamin D outside of
its traditional role in metabolic bone disease. Some nontraditional roles ascribed to vitamin …

Recent advances in the understanding of bile acid malabsorption

S Pattni, JRF Walters - British medical bulletin, 2009 - academic.oup.com
Introduction Bile acid malabsorption (BAM) is a syndrome of chronic watery diarrhoea with
excess faecal bile acids. Disruption of the enterohepatic circulation of bile acids following …

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

DA Van Heel, L Franke, KA Hunt, R Gwilliam… - Nature …, 2007 - nature.com
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422
controls. Outside the HLA region, the most significant finding (rs13119723; P= 2.0× 10− 7) …

Newly identified genetic risk variants for celiac disease related to the immune response

KA Hunt, A Zhernakova, G Turner, GAR Heap… - Nature …, 2008 - nature.com
Our genome-wide association study of celiac disease previously identified risk variants in
the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most …

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

A Akbar, Y Yiangou, P Facer, JRF Walters, P Anand… - Gut, 2008 - gut.bmj.com
Objective: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may
play an important role in visceral pain and hypersensitivity states. In irritable bowel …

The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control

DJ Pournaras, C Glicksman, RP Vincent… - …, 2012 - academic.oup.com
Gastric bypass leads to the remission of type 2 diabetes independently of weight loss. Our
hypothesis is that changes in bile flow due to the altered anatomy may partly explain the …

A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis

JRF Walters, AM Tasleem, OS Omer, WG Brydon… - Clinical …, 2009 - Elsevier
BACKGROUND & AIMS: Primary (idiopathic) bile acid malabsorption (BAM) is a common,
yet underrecognized, chronic diarrheal syndrome. Diagnosis is difficult without selenium …

Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology

RP Arasaradnam, S Brown, A Forbes, MR Fox… - Gut, 2018 - gut.bmj.com
Chronic diarrhoea is a common problem, hence clear guidance on investigations is
required. This is an updated guideline from 2003 for the investigations of chronic diarrhoea …

Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain

A Akbar, Y Yiangou, P Facer, WG Brydon, JRF Walters… - Gut, 2010 - gut.bmj.com
Objective Transient receptor potential vanilloid type 1 (TRPV1) has been shown to play an
important role in visceral hypersensitivity. A significant proportion of patients with …