Aryl hydrocarbon receptor ligands in cancer: friend and foe
IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
Indole and tryptophan metabolism: endogenous and dietary routes to Ah receptor activation
TD Hubbard, IA Murray, GH Perdew - Drug Metabolism and Disposition, 2015 - ASPET
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor recognized for
its role in xenobiotic metabolism. The physiologic function of AHR has expanded to include …
its role in xenobiotic metabolism. The physiologic function of AHR has expanded to include …
[PDF][PDF] O-Acetyltransferases for chloramphenicol and other natural products
IA Murray, WV Shaw - Antimicrobial agents and chemotherapy, 1997 - Am Soc Microbiol
The range of enzymatic mechanisms by which bacteria inactivate biologically active
molecules is limited by two kinds of constraint, namely, the structure-activity correlations for …
molecules is limited by two kinds of constraint, namely, the structure-activity correlations for …
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
BC DiNatale, IA Murray, JC Schroeder… - Toxicological …, 2010 - academic.oup.com
Inflammatory signaling plays a key role in tumor progression, and the pleiotropic cytokine
interleukin-6 (IL-6) is an important mediator of protumorigenic properties. Activation of the …
interleukin-6 (IL-6) is an important mediator of protumorigenic properties. Activation of the …
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
G Fang, D Munera, DI Friedman, A Mandlik… - Nature …, 2012 - nature.com
Single-molecule real-time (SMRT) DNA sequencing allows the systematic detection of
chemical modifications such as methylation but has not previously been applied on a …
chemical modifications such as methylation but has not previously been applied on a …
Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study
AJ Stanley, L Laine, HR Dalton, JH Ngu, M Schultz… - bmj, 2017 - bmj.com
Objective To compare the predictive accuracy and clinical utility of five risk scoring systems
in the assessment of patients with upper gastrointestinal bleeding. Design International …
in the assessment of patients with upper gastrointestinal bleeding. Design International …
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
TA Clark, IA Murray, RD Morgan… - Nucleic acids …, 2012 - academic.oup.com
DNA methylation is the most common form of DNA modification in prokaryotic and eukaryotic
genomes. We have applied the method of single-molecule, real-time (SMRT®) DNA …
genomes. We have applied the method of single-molecule, real-time (SMRT®) DNA …
[HTML][HTML] Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
TD Hubbard, IA Murray, WH Bisson, TS Lahoti… - Scientific reports, 2015 - nature.com
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the
immunological status of the gastrointestinal tract, establishing and maintaining signaling …
immunological status of the gastrointestinal tract, establishing and maintaining signaling …
The methylomes of six bacteria
Six bacterial genomes, Geobacter metallireducens GS-15, Chromohalobacter salexigens,
Vibrio breoganii 1C-10, Bacillus cereus ATCC 10987, Campylobacter jejuni subsp. jejuni 81 …
Vibrio breoganii 1C-10, Bacillus cereus ATCC 10987, Campylobacter jejuni subsp. jejuni 81 …
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
L Zhang, RG Nichols, J Correll, IA Murray… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Alteration of the gut microbiota through diet and environmental contaminants
may disturb physiological homeostasis, leading to various diseases including obesity and …
may disturb physiological homeostasis, leading to various diseases including obesity and …