Alcohol is a major cause of liver cirrhosis in the Western world and accounts for the majority
of cases of liver cirrhosis seen in district general hospitals in the UK. The three most widely …

Populations in developed countries continue to grow older and an understanding of the
ageing process to allow healthy ageing carries important medical implications. Older …

Cellular senescence is a fundamental, complex mechanism with an important protective role
present from embryogenesis to late life across all species. It limits the proliferative potential …

The successful use of orthotopic liver transplantation in fulminant hepatic failure has created
a need for early prognostic indicators to select the patients most likely to benefit at a time …

Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United
States, with estimates of 4 million HCV-infected individuals in the United States and 170 …

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory
and activation receptors for major histocompatibility complex class I molecules as a means …

Background The role of liver transplantation in patients positive for the hepatitis B surface
antigen (HBsAg) is controversial because of the high rate of recurrent hepatitis B virus (HBV) …

While patients with liver disease are known to have a higher prevalence of glucose
intolerance, preliminary studies suggest that hepatitis C virus (HCV) infection may be an …

Background. When administered early after an overdose of acetaminophen, intravenous
acetylcysteine prevents hepatic necrosis by replenishing reduced stores of glutathione. How …

Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for
regenerative medicine because they offer the prospect of generating unlimited quantities of …