[HTML][HTML] Anti-tuberculosis treatment strategies and drug development: challenges and priorities

VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Bacterial growth and cell division: a mycobacterial perspective

EC Hett, EJ Rubin - Microbiology and molecular biology reviews, 2008 - Am Soc Microbiol
The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

[HTML][HTML] Latent tuberculosis infection in the United States

CR Horsburgh Jr, EJ Rubin - New England Journal of Medicine, 2011 - Mass Medical Soc
This article reviews recommended strategies for screening and treatment of latent
tuberculosis in the United States, with attention to the role of interferon-γ–release assays in …

Genes required for mycobacterial growth defined by high density mutagenesis

CM Sassetti, DH Boyd, EJ Rubin - Molecular microbiology, 2003 - Wiley Online Library
Despite over a century of research, tuberculosis remains a leading cause of infectious death
worldwide. Faced with increasing rates of drug resistance, the identification of genes that are …

Genetic requirements for mycobacterial survival during infection

CM Sassetti, EJ Rubin - Proceedings of the National …, 2003 - National Acad Sciences
Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages

J Rengarajan, BR Bloom… - Proceedings of the …, 2005 - National Acad Sciences
Macrophages are central to host defense against microbes, but intracellular pathogens have
evolved to evade their antimicrobial functions. Mycobacterium tuberculosis (MTB) has …

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

MR Farhat, BJ Shapiro, KJ Kieser, R Sultana… - Nature …, 2013 - nature.com
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis
epidemic control. Mechanisms of resistance, including genetic changes favored by selection …

Comprehensive identification of conditionally essential genes in mycobacteria

CM Sassetti, DH Boyd… - Proceedings of the …, 2001 - National Acad Sciences
An increasing number of microbial genomes have been completely sequenced, and the
identified genes are categorized based on their homology to genes of known function …

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

MA DeJesus, ER Gerrick, W Xu, SW Park, JE Long… - MBio, 2017 - Am Soc Microbiol
For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on mapping integration sites in libraries of random transposon mutants to …

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

BJ Akerley, EJ Rubin, VL Novick… - Proceedings of the …, 2002 - National Acad Sciences
A high-density transposon mutagenesis strategy was applied to the Haemophilus influenzae
genome to identify genes required for growth or viability. This analysis detected putative …