Cardiovascular effects of fine and ultrafine particles

H Schulz, V Harder, A Ibald-Mulli… - Journal of aerosol …, 2005 - liebertpub.com
Epidemiological studies of the past decades have provided a strong body of evidence that
elevated levels of ambient particulate air pollution (PM) are associated with increased …

[HTML][HTML] The MONICA Augsburg surveys-basis for prospective cohort studies

H Löwel, A Döring, A Schneider, M Heier… - Das …, 2005 - thieme-connect.com
Zusammenfassung Als Teil des WHO-MONICA-Projektes sind seit 1984/85 drei
bevölkerungsrepräsentative Querschnittsstudien in der Region Augsburg durchgeführt …

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

BF Voight, LJ Scott, V Steinthorsdottir, AP Morris… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

A Mahajan, D Taliun, M Thurner, NR Robertson… - Nature …, 2018 - nature.com
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …

Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease: meta-analysis of six population-based cohorts

C Herder, T De Las Heras Gala… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Interleukin (IL)-1β represents a key cytokine in the development of
cardiovascular disease (CVD). IL-1β is counter-regulated by IL-1 receptor antagonist (IL …

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Novel biomarkers for pre‐diabetes identified by metabolomics

R Wang‐Sattler, Z Yu, C Herder… - Molecular systems …, 2012 - embopress.org
Type 2 diabetes (T2D) can be prevented in pre‐diabetic individuals with impaired glucose
tolerance (IGT). Here, we have used a metabolomics approach to identify candidate …

Mendelian randomization of blood lipids for coronary heart disease

MV Holmes, FW Asselbergs, TM Palmer… - European heart …, 2015 - academic.oup.com
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for …

An expanded genome-wide association study of type 2 diabetes in Europeans

RA Scott, LJ Scott, R Mägi, L Marullo, KJ Gaulton… - Diabetes, 2017 - Am Diabetes Assoc
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …

Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels

A Dehghan, J Dupuis, M Barbalic, JC Bis… - Circulation, 2011 - Am Heart Assoc
Background—C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …