User profiles for "author:Anand Jeyasekharan"
Anand D JeyasekharanAssistant Professor (Medicine), National University of Singapore Verified email at nus.edu.sg Cited by 4234 |
[HTML][HTML] ROS and the DNA damage response in cancer
US Srinivas, BWQ Tan, BA Vellayappan… - Redox biology, 2019 - Elsevier
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …
containing molecules that can induce DNA damage and affect the DNA damage response …
Biomarkers for homologous recombination deficiency in cancer
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …
repair pathway of clinical interest due to the sensitivity of homologous recombination …
[HTML][HTML] Molecular pathogenic pathways in extranodal NK/T cell lymphoma
S de Mel, SSS Hue, AD Jeyasekharan… - Journal of hematology & …, 2019 - Springer
Extranodal NK/T cell lymphoma, nasal type (ENKTL) is an aggressive malignancy with a
dismal prognosis. Although l-asparaginase-based chemotherapy has resulted in improved …
dismal prognosis. Although l-asparaginase-based chemotherapy has resulted in improved …
HP1-β mobilization promotes chromatin changes that initiate the DNA damage response
Minutes after DNA damage, the variant histone H2AX is phosphorylated by protein kinases
of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (γ) …
of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (γ) …
[HTML][HTML] Choice of PD-L1 immunohistochemistry assay influences clinical eligibility for gastric cancer immunotherapy
Background Immune checkpoint inhibitors (ICI) are now standard-of-care treatment for
patients with metastatic gastric cancer (GC). To guide patient selection for ICI therapy …
patients with metastatic gastric cancer (GC). To guide patient selection for ICI therapy …
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
H Khoury-Haddad, N Guttmann-Raviv… - Proceedings of the …, 2014 - National Acad Sciences
Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
[HTML][HTML] Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS
CMM Wai, S Chen, T Phyu, S Fan, SM Leong… - …, 2022 - ncbi.nlm.nih.gov
Abstract Primary Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (PTCL-EBV) is
a poorly understood disease which shows features resembling extranodal NK/T-cell …
a poorly understood disease which shows features resembling extranodal NK/T-cell …
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
AD Jeyasekharan, Y Liu, H Hattori, V Pisupati… - Nature structural & …, 2013 - nature.com
Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer.
Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated …
Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated …
[HTML][HTML] Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes
SB Ng, TH Chung, S Kato, S Nakamura… - …, 2018 - ncbi.nlm.nih.gov
The molecular biology of primary nodal T-and NK-cell lymphoma and its relationship with
extranodal NK/T-cell lymphoma, nasal type is poorly understood. In this study, we assessed …
extranodal NK/T-cell lymphoma, nasal type is poorly understood. In this study, we assessed …
[PDF][PDF] The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry
Summary Background The Rad51 recombinase assembles on DNA to execute homologous
DNA recombination (HR). This process is essential to repair replication-associated genomic …
DNA recombination (HR). This process is essential to repair replication-associated genomic …