User profiles for "author:Anand Jeyasekharan"

Anand D Jeyasekharan

Assistant Professor (Medicine), National University of Singapore
Verified email at nus.edu.sg
Cited by 4234

[HTML][HTML] ROS and the DNA damage response in cancer

US Srinivas, BWQ Tan, BA Vellayappan… - Redox biology, 2019 - Elsevier
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Biomarkers for homologous recombination deficiency in cancer

MM Hoppe, R Sundar, DSP Tan… - JNCI: Journal of the …, 2018 - academic.oup.com
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …

[HTML][HTML] Molecular pathogenic pathways in extranodal NK/T cell lymphoma

S de Mel, SSS Hue, AD Jeyasekharan… - Journal of hematology & …, 2019 - Springer
Extranodal NK/T cell lymphoma, nasal type (ENKTL) is an aggressive malignancy with a
dismal prognosis. Although l-asparaginase-based chemotherapy has resulted in improved …

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

N Ayoub, AD Jeyasekharan, JA Bernal… - Nature, 2008 - nature.com
Minutes after DNA damage, the variant histone H2AX is phosphorylated by protein kinases
of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (γ) …

[HTML][HTML] Choice of PD-L1 immunohistochemistry assay influences clinical eligibility for gastric cancer immunotherapy

J Yeong, HYJ Lum, CB Teo, BKJ Tan, YH Chan… - Gastric Cancer, 2022 - Springer
Background Immune checkpoint inhibitors (ICI) are now standard-of-care treatment for
patients with metastatic gastric cancer (GC). To guide patient selection for ICI therapy …

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

H Khoury-Haddad, N Guttmann-Raviv… - Proceedings of the …, 2014 - National Acad Sciences
Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …

[HTML][HTML] Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS

CMM Wai, S Chen, T Phyu, S Fan, SM Leong… - …, 2022 - ncbi.nlm.nih.gov
Abstract Primary Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (PTCL-EBV) is
a poorly understood disease which shows features resembling extranodal NK/T-cell …

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

AD Jeyasekharan, Y Liu, H Hattori, V Pisupati… - Nature structural & …, 2013 - nature.com
Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer.
Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated …

[HTML][HTML] Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes

SB Ng, TH Chung, S Kato, S Nakamura… - …, 2018 - ncbi.nlm.nih.gov
The molecular biology of primary nodal T-and NK-cell lymphoma and its relationship with
extranodal NK/T-cell lymphoma, nasal type is poorly understood. In this study, we assessed …

[PDF][PDF] The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

N Ayoub, E Rajendra, X Su, AD Jeyasekharan… - Current Biology, 2009 - cell.com
Summary Background The Rad51 recombinase assembles on DNA to execute homologous
DNA recombination (HR). This process is essential to repair replication-associated genomic …