State of the iron: how to diagnose and efficiently treat iron deficiency anemia in inflammatory bowel disease

Walter Reinisch; Michael Staun; Sunil Bhandari; Manuel Muñoz

doi:10.1016/j.crohns.2012.07.031

State of the iron: how to diagnose and efficiently treat iron deficiency anemia in inflammatory bowel disease

J Crohns Colitis. 2013 Jul;7(6):429-40. doi: 10.1016/j.crohns.2012.07.031. Epub 2012 Aug 20.

Authors

Walter Reinisch¹, Michael Staun, Sunil Bhandari, Manuel Muñoz

Affiliation

¹ Medical University of Vienna, Austria. walter.reinisch@meduniwien.ac.at

PMID: 22917870
DOI: 10.1016/j.crohns.2012.07.031

Abstract

Iron deficiency anemia (IDA) frequently occurs in patients suffering from inflammatory bowel disease (IBD) and negatively impacts their quality of life. Nevertheless, the condition appears to be both under-diagnosed and undertreated. Regular biochemical screening of patients with IBD for anemia by the gastroenterology community has to be advocated. Oral iron is a low cost treatment however its effectiveness is limited by low bioavailability and poor tolerability. Intravenous (IV) iron rapidly replenishes iron stores and has demonstrated its safe use in a number of studies in various therapeutic areas. A broad spectrum of new IV iron formulations is now becoming available offering improved tolerability and patient convenience by rapidly restoring the depleted iron status of patients with IBD. The following article aims to review the magnitude of the problem of IDA in IBD, suggest screening standards and highlight existing and future therapies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Algorithms
Anemia, Iron-Deficiency / diagnosis*
Anemia, Iron-Deficiency / drug therapy*
Anemia, Iron-Deficiency / etiology
Clinical Trials as Topic
Diagnosis, Differential
Disaccharides / pharmacology
Disaccharides / therapeutic use
Dose-Response Relationship, Drug
Ferric Compounds / pharmacology
Ferric Compounds / therapeutic use
Ferric Oxide, Saccharated
Ferrosoferric Oxide / pharmacology
Ferrosoferric Oxide / therapeutic use
Glucaric Acid / pharmacology
Glucaric Acid / therapeutic use
Hematinics / pharmacology
Hematinics / therapeutic use
Humans
Inflammatory Bowel Diseases / complications*
Infusions, Intravenous
Iron Deficiencies
Maltose / analogs & derivatives
Maltose / pharmacology
Maltose / therapeutic use
Prevalence
Thrombocytosis / etiology
Thromboembolism / etiology

Substances

Disaccharides
Ferric Compounds
Hematinics
iron isomaltoside 1000
ferric carboxymaltose
Maltose
Ferric Oxide, Saccharated
Glucaric Acid
Ferrosoferric Oxide