Abstract
The prevalence of obesity and related disorders such as metabolic syndrome has vastly increased throughout the world. Recent insights have generated an entirely new perspective suggesting that our microbiota might be involved in the development of these disorders. Studies have demonstrated that obesity and metabolic syndrome may be associated with profound microbiotal changes, and the induction of a metabolic syndrome phenotype through fecal transplants corroborates the important role of the microbiota in this disease. Dietary composition and caloric intake appear to swiftly regulate intestinal microbial composition and function. As most findings in this field of research are based on mouse studies, the relevance to human biology requires further investigation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bacteria / drug effects
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Bacteria / metabolism
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Bacterial Translocation
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Dietary Carbohydrates / pharmacokinetics
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Dietary Carbohydrates / pharmacology
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Dietary Fats / pharmacokinetics
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Dietary Fats / pharmacology
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Digestion
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Disease Models, Animal
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Energy Metabolism
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Gastrointestinal Tract / microbiology*
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Genetic Predisposition to Disease
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Germ-Free Life
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Humans
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Inflammation
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Metabolic Diseases / etiology
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Metabolic Diseases / immunology
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Metabolic Diseases / microbiology*
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Metabolic Diseases / physiopathology
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Metabolic Networks and Pathways
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Metagenome / drug effects
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Metagenome / physiology*
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Mice
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Mice, Mutant Strains
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Obesity / etiology
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Obesity / genetics
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Obesity / immunology
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Obesity / microbiology*
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Obesity / physiopathology
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Species Specificity
Substances
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Dietary Carbohydrates
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Dietary Fats