Colonoscopy is the preferred method of screening for colorectal cancer in women. The longer, more redundant female colon is frequently more difficult for the endoscopist to navigate and most studies show longer insertion times, lower completion rates, and more discomfort associated with the procedure in women, all of which may be exacerbated by hysterectomy. To improve female patients' compliance with colorectal cancer screening we need to understand the barriers to participation prevalent among women. This article reviews the findings of several studies and discusses some steps to improve cancer screening for women.