Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Hypomagnesemia Associated with a Proton Pump Inhibitor
Jun MatsuyamaKunihiro TsujiHisashi DoyamaFae KimYasuhito TakedaYosuke KitoRenma ItoHiroyoshi NakanishiTomoyuki HayashiYohei WasedaShigetsugu TsujiKenichi TakemuraShinya YamadaToshihide OkadaHonin Kanaya
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JOURNAL OPEN ACCESS

2012 Volume 51 Issue 16 Pages 2231-2234

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Abstract

Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral ankle arthritis, and tremor of the extremities who had convulsions 3 days after admission. Blood analysis showed severe hypomagnesemia. He had been taking rabeprazole (10 mg/day) for 5 years. After stopping rabeprazole and correcting the electrolytes imbalances, his symptoms improved without recurrence.

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© 2012 by The Japanese Society of Internal Medicine
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