Original ArticlesA randomized single-blind trial of whole versus split-dose polyethylene glycol-electrolyte solution for colonoscopy preparation☆,☆☆
Section snippets
Patients
Ambulatory patients seen on an outpatient basis and scheduled for an elective colonoscopy were enrolled in the study. Exclusion criteria were the following: age under 18 years; the presence of serious conditions such as severe cardiac, renal, or metabolic diseases; active alcoholism, drug addiction, or major psychiatric illness; known allergy to PEG or bisacodyl; and refusal to consent to the study. The study was conducted between September 1, 2001, and April 30, 2002. After obtaining informed
Results
One hundred eighty-seven patients (83 women, 104 men; mean age, 56 years; range 18-91 years) were recruited for the study, 96 randomized to Group A and 91 to Group B (Table 2).Empty Cell Group A (n = 96) n (%) Group B (n = 91) n (%) p Value Age, range (y) 18-91 21-84 — Age, mean (y) (SD) 56 (14) 55 (13) — Gender, F:M (ratio) 1.1:1 1:1.8 0.04 Indication Anemia 9 (9%) 2 (2%) 0.08 Abdominal pain 22 (23%) 21 (23%) 1.0 Rectal bleeding 19 (20%) 25 (28%) 0.3 Follow-up
Discussion
Colonoscopy is the method of choice for evaluation of the large bowel and terminal ileum for both diagnostic and therapeutic purposes. The difficulty and duration of the procedure depend in part on the adequacy of bowel cleansing. For the last two decades, ingestion of the PEG-electrolyte solution has been the standard method for preparing patients for colonoscopy, with excellent bowel preparation being achieved by a large number of patients with no significant effects on the extra- and
References (16)
- et al.
Development of a lavage solution associated with minimal water and electrolyte absorption or secretion
Gastroenterology
(1980) - et al.
Sodium phosphate preparation for colonoscopy: onset and duration of bowel activity
Gastrointest Endosc
(1999) - et al.
Meta-analysis and cost comparison of polyethylene glycol lavage versus sodium phosphate for colonoscopy preparation
Gastrointest Endosc
(1998) - et al.
Oral sodium phosphate versus sulfate-free polyethylene glycol electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison
Gastrointest Endosc
(1996) - et al.
Single day, divided-dose oral sodium phosphate laxative versus intestinal lavage as preparation for colonoscopy: efficacy and patient tolerance
Gastrointest Endosc
(1995) - et al.
Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation
Gastrointest Endosc
(1998) - et al.
Oral sodium phosphate versus sulfate free PEG electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison
Gastrointest Endosc
(1996) - et al.
Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine
Gastrointest Endosc
(1996)
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The Bowel CLEANsing National Initiative: High-Volume Split-Dose Vs Low-Volume Split-Dose Polyethylene Glycol Preparations: A Randomized Controlled Trial
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2017, Digestive and Liver DiseaseCitation Excerpt :On this basis, the development of new regimens (full or split) and formulations for bowel cleansing with a higher degree of tolerability is desirable. Some clinical trials have shown how split-dose PEG solution results in a marked increase in tolerability which improves overall bowel preparation quality [15–18]. This effect was also observed in our study: the rate of successful bowel cleansing were significantly higher with the split-dose regimen than with the full dose the day before for both low and high volume bowel preparations.
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