Clinical–alimentary tractPrevalence of Barrett’s Esophagus in the General Population: An Endoscopic Study
Section snippets
Setting
The setting consisted of 2 neighboring communities in northern Sweden, Kalix and Haparanda, with 18,408 and 10,580 inhabitants, respectively (as of December 1998). The age and sex distribution was similar to the national average in Sweden.19
This study was approved by the Umeå University Ethics Committee and conducted in accordance with the revised Declaration of Helsinki in 1998.
Sampling
By using the computerized national population register, covering all citizens in the 2 communities by date of birth
Endoscopy
Suspected CLE was found in 103 cases (10.3%; mean age, 55.7 years; 60.2% men). Twelve of them (1.2%) with a mean age of 59 years (7 men) had a long segment. Of the 87 suspected CLE cases without SIM in the biopsy specimens, there were 83 cases with columnar epithelium, 3 with squamous epithelium, and 1 with missing biopsy specimens. Hence, 96.1% of the suspected CLE had columnar epithelium in the biopsy specimens. On biopsy specimens from the distal esophagus and gastroesophageal junction, 60
Discussion
Within the framework of a population-based study using endoscopy, we have examined the prevalence of BE and associated risk factors. The cohort represents a random unselected adult population. We found that the prevalence of BE was 1.6% (LSBE, 0.5%; SSBE, 1.1%).
This prevalence of BE is in accordance with recently reported prevalence figures in large selected cohorts.15, 16 The prevalence of LSBE (0.5%) is also only modestly higher than that reported in the 1990 study by Cameron et al, in which
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Supported in part by the Swedish Research Council, the Swedish Society of Medicine, Mag-tarm sjukas förbund, Norrbotten County Council (Sweden), and AstraZeneca R&D (Sweden).