Original articleClinical endoscopySecond-generation colon capsule endoscopy compared with colonoscopy
Section snippets
Patients and methods
A total of 8 European sites participated in this prospective study. Recruitment began August 28, 2009 and ended July 7, 2010. Patients (18-80 years of age) who were scheduled to undergo colonoscopy for either known or suspected colonic disease were enrolled in the study. Indications included colorectal cancer screening; personal history of colorectal cancer or adenomatous polyps and at least 3 years since last conventional colonoscopy; clinical symptoms such as rectal bleeding, positive fecal
Results
The 8 participating centers enrolled 117 patients (mean ± SD age 60 ± 9 years; 72 men). Clinical indications for colonoscopy are provided in Table 1. Eight of 117 patients (6.8%) were excluded from the efficacy analysis for the following reasons: inability to swallow the capsule (1 case), technical failure of the data recorder (2 cases), and capsule technical failure (2 cases). In two cases, the capsule remained in the cecum during the entire procedure, and one patient withdrew consent to
Discussion
Our prospective, multicenter study showed a sensitivity as high as 84% and 88% for ≥6-mm and ≥10-mm polyps, respectively, when comparing CCE-2 with colonoscopy. These results are well in line with the colon capsule endoscopy–sensitivity values of 89% and 88% assessed in the previous Israeli study,8 confirming the high colon capsule endoscopy sensitivity for clinically relevant lesions. Of note, the mean age of the patients included in our study—that is, 60 years—is more similar to that of an
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DISCLOSURE: C. Spada, C. Hassan, H. Neuhaus, J. Deviere, A. Van Gossum, S. Sacher-Huvelin, J-P Galmiche, and G. Costamagna are speakers for Given Imaging Ltd. J. Deviere, J-P Galmiche, and G. Costamagna have received research grants from Given Imaging Ltd. No other financial relationships relevant to this publication were disclosed.
If you would like to chat with an author of this article, you may contact Dr Spada at [email protected].