Original articlesLong-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County
Section snippets
Ulcerative colitis cohort
From 1962 to 1987 a total of 1161 patients living in Copenhagen County had a diagnosis of UC and these patients previously were enrolled in a population-based cohort. The region on the island of Zealand consists of 16 municipalities surrounding central Copenhagen. The area is 443.5 km2 and counted 557,500 inhabitants in 2000.16 The case ascertainment and inclusion of patients were performed according to well-defined diagnostic criteria.17 All the patients initially were followed-up with annual
Results
The cohort was observed for a total of 22,290 person-years with a median follow-up period of 19 years (range, 1–36 y). One male patient was excluded from the cohort owing to residency outside Copenhagen County at the time of diagnosis, thus decreasing the number of patients from 1161 to 1160. There were 541 men observed for 9946 person-years and 619 women contributing 12,344 person-years. The follow-up evaluation was complete except for 1 patient (99.9%). Sixteen patients had emigrated (1.4%)
Discussion
The present population-based study comprising 1160 patients followed-up for a median of 19 years, or a total of 22,290 person-years, shows no overall increased risk for either CRC or cancer in general. This positive result now confirms the previously reported low occurrence of CRC that was found in this cohort after follow-up evaluation until 1987.15 The cumulative risk for CRC was only 0.4% by 10 years, 1.1% by 20 years, and 2.1% by 30 years in the present cohort of UC patients. For
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This article is part of a doctoral thesis (K.V.W.).
Published in abstract form in Gastroenterology 2000;117:A289; Gut 2000;47(Suppl III):A5 and A32; and Cancer Detection and Prevention 2000;24:S181.
Supported by the Danish Cancer Society grants 9810035 and DP 00007, by the Agnes and Poul Friis Foundation, and by the Beckett Foundation.