Elsevier

The Lancet

Volume 345, Issue 8958, 6 May 1995, Pages 1183-1184
The Lancet

Letters to the Editor
Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome)

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    In 1990, the International Collaborative Group on HNPCC (now International Society for Gastrointestinal Hereditary Tumours, InSiGHT) recommended a surveillance interval of 2 to 3 years.5 However, a few years later, reports appeared describing patients who seemed to have developed a cancer within 2 to 3 years after a normal colonoscopy.20 Other studies also indicated that the adenoma-carcinoma sequence in LS might be accelerated.21–23

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