International Journal of Radiation Oncology*Biology*Physics
Original ContributionFailure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation
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Cited by (24)
Effects of lactose-free and low-lactose dairy on symptoms of gastrointestinal health: A systematic review
2021, International Dairy JournalCitation Excerpt :The study by Onwulata et al. (1989) found that gastrointestinal symptoms were correlated with a higher breath hydrogen level (P < 0.05). Out of the 23 studies, 4 measured stool frequency and consistency after consuming lactose-containing dairy products compared to lactose-free or low lactose dairy products (Järvinen et al., 2003; Seppänen et al., 2008; Stryker & Bartholomew, 1986; Tinmouth et al., 2006). The two-week study by Seppänen et al. (2008) reported more regular bowel function when consuming lactose-free milk compared with increased stool consistency and frequency when consuming whole milk (P < 0.0001) with participants consuming either lactose-free milk or whole milk with a 1 week washout period.
Small bowel bacterial overgrowth and lactose intolerance during radical pelvic radiotherapy: An observational study
2008, European Journal of CancerCitation Excerpt :Two previous studies reported that lactose intolerance develops in up to 45% of all patients during radiotherapy. However, a well conducted randomised clinical trial based on these data suggested no benefit from a lactose-free diet 21, suggesting that either this figure of 45% was excessive, or other physiological defects (such as small bowel bacterial overgrowth) were also contributing to symptoms in many patients. The use of conformal radiotherapy, as used in our patients, may often help reduce the exposure of the small bowel to radiation and the subsequent development of lactose intolerance 10, thus our finding of 15% of patients developing new-onset lactose intolerance also seems plausible.
Gastrointestinal symptoms after pelvic radiotherapy: Role for the gastroenterologist?
2005, International Journal of Radiation Oncology Biology PhysicsPhase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy
2005, Radiotherapy and Oncology
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Department of Radiology, Division of Radiation Oncology.
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Statistician, Department of Behavioral Sciences.