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Biliary complications after deceased-donor orthotopic liver transplantation

  • Topics: Biliary complications after liver transplantation
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

A wide range of potential biliary complications can occur after orthotopic liver transplantation (OLT). The most common biliary complications are bile leaks, anastomotic and intrahepatic strictures, stones, and ampullary dyfunction, which may occur in up to 20%–40% of OLT recipients. Leaks predominate in the early posttransplant period; stricture formation typically develops gradually over time. However, with the advent of new techniques, such as split-liver, reduced-size, and living-donor liver transplantation, the spectrum of biliary complications has changed. Risk factors for biliary complications comprise technical failure; T-tube or stent-related complications; hepatic artery thrombosis; bleeding; ischemia/reperfusion injury; and other immunological, nonimmunological, and infectious complications. Noninvasive diagnostic methods have been established and treatment modalities have been modified towards a primarily nonoperative, endoscopy-based strategy. Besides, the management of biliary complications after OLT requires a multidisciplinary approach, in which interventional and endoscopic treatment options have to be weighed up against surgical treatment options. The etiology and spectrum of bile duct complications, their diagnosis, and their treatment will be reviewed in this article.

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References

  1. BY Tung MB Kimmey (1999) ArticleTitleBiliary complications of orthotopic liver transplantation Dig Dis 17 133–44 Occurrence Handle10697662 Occurrence Handle1:STN:280:DC%2BD3c7mt1Oksg%3D%3D Occurrence Handle10.1159/000016918

    Article  PubMed  CAS  Google Scholar 

  2. PR Pfau ML Kochman JD Lewis WB Long MR Lucey K Olthoff et al. (2000) ArticleTitleEndoscopic management of postoperative biliary complications in orthotopic liver transplantation Gastrointest Endosc 52 55–63 Occurrence Handle10882963 Occurrence Handle1:STN:280:DC%2BD3cvlslyitA%3D%3D Occurrence Handle10.1067/mge.2000.106687

    Article  PubMed  CAS  Google Scholar 

  3. S Jagganath AN Kaloo (2002) ArticleTitleBiliary complications after liver transplantation Curr Treat Options Gastroenterol 5 101–12

    Google Scholar 

  4. PJ Thuluvath PR Pfau MB Kimmey GG Ginsberg (2005) ArticleTitleBiliary complications after liver transplantation: the role of endoscopy Endoscopy 37 857–63 Occurrence Handle16116539 Occurrence Handle1:STN:280:DC%2BD2MvkvVygtg%3D%3D Occurrence Handle10.1055/s-2005-870192

    Article  PubMed  CAS  Google Scholar 

  5. F Grief OL Bronsther DH VanThiel A Casavilla S Iwatsuki A Tzakis et al. (1994) ArticleTitleThe incidence, timing and management of biliary tract complications after orthotopic liver transplantation Ann Surg 219 40–5

    Google Scholar 

  6. P Boraschi G Braccini R Gigoni G Sartoni E Neri F Filipponi et al. (2001) ArticleTitleDetection of biliary complications after orthotopic liver transplantation with MR cholangiography Magn Reson Imaging 19 1097–105 Occurrence Handle11711234 Occurrence Handle1:STN:280:DC%2BD3Mnms1Sntg%3D%3D Occurrence Handle10.1016/S0730-725X(01)00443-X

    Article  PubMed  CAS  Google Scholar 

  7. JY Sung JW Costerton EA Shaffer (1992) ArticleTitleDefense system in the biliary tract against bacterial infection Dig Dis Sci 37 689–96 Occurrence Handle1563308 Occurrence Handle1:STN:280:DyaK383isVOksw%3D%3D Occurrence Handle10.1007/BF01296423

    Article  PubMed  CAS  Google Scholar 

  8. P Neuhaus G Blumhardt WO Bechstein R Steffen KP Platz H Keck (1994) ArticleTitleTechnique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants Ann Surg 219 426–34 Occurrence Handle8161269 Occurrence Handle1:STN:280:DyaK2c3htlGmtw%3D%3D Occurrence Handle10.1097/00000658-199404000-00014

    Article  PubMed  CAS  Google Scholar 

  9. H Keck JM Langrehr G Blumhardt et al. (1994) ArticleTitleIncidence of biliary complications following side-to-side choledochocholedochostomy after liver transplantation Transplant Proc 26 3544–5 Occurrence Handle7998269 Occurrence Handle1:STN:280:DyaK2M%2FptVyqtA%3D%3D

    PubMed  CAS  Google Scholar 

  10. JM Rabkin SL Orloff MH Reed LJ Wheeler CL Corless KG Benner et al. (1998) ArticleTitleBiliary tract complications of side-to-side without T-tube versus end-to-end with or without T-tube choledochocholedochostomy in liver transplant recipients Transplantation 65 193–9 Occurrence Handle9458013 Occurrence Handle1:STN:280:DyaK1c7hslaitQ%3D%3D Occurrence Handle10.1097/00007890-199801270-00008

    Article  PubMed  CAS  Google Scholar 

  11. BR Davidson R Rai TR Kurzawinski L Selves M Farouk JS Dooley et al. (1999) ArticleTitleProspective randomized trial of end-to-end versus side-to-side biliary reconstruction after orthotopic liver transplantation Br J Surg 86 447–52 Occurrence Handle10215812 Occurrence Handle1:STN:280:DyaK1M3jtlOmtQ%3D%3D Occurrence Handle10.1046/j.1365-2168.1999.01073.x

    Article  PubMed  CAS  Google Scholar 

  12. A Shaked (1997) ArticleTitleUse of T-tube in liver transplantation Liver Transplant Surg 3 IssueIDSuppl 22–3

    Google Scholar 

  13. MK Porayko M Kondo JL Steers (1995) ArticleTitleLiver transplantation: late complications of the biliary tract and their management Semin Liver Dis 15 139–55 Occurrence Handle7660167 Occurrence Handle1:STN:280:DyaK2MzovFaisA%3D%3D

    PubMed  CAS  Google Scholar 

  14. JW Ostroff JP Roberts RL Gordon EJ Ring NL Ascher (1990) ArticleTitleThe management of T-tube leaks in orthotopic liver transplant recipients with endoscopically placed nasobiliary catheters Transplantation 49 922–4 Occurrence Handle2336710 Occurrence Handle1:STN:280:DyaK3c3ks1GisA%3D%3D Occurrence Handle10.1097/00007890-199005000-00018

    Article  PubMed  CAS  Google Scholar 

  15. TP O'Connor D Lewis RL Jenkins (1995) ArticleTitleBiliary tract complications after liver transplantation Arch Surg 130 312–7 Occurrence Handle7887800

    PubMed  Google Scholar 

  16. MC Shuhart KV Kowdley JP McVicar CA Rohmann MF McDonald DW Wadland et al. (1998) ArticleTitlePredictors of bile leaks after T-tube removal in orthotopic liver transplant recipients Liver Transplant Surg 4 62–70 Occurrence Handle1:STN:280:DyaK1c7hslWksQ%3D%3D Occurrence Handle10.1002/lt.500040109

    Article  CAS  Google Scholar 

  17. L Grande A Pérez-Castilla D Matus C Ridriguez-Montalve A Rimola M Navasa et al. (1999) ArticleTitleRoutine use of the T-tube in the biliary reconstruction of liver transplantation: is it worthwhile? Transplant Proc 31 2396–7 Occurrence Handle10500637 Occurrence Handle1:STN:280:DyaK1MvjtVChtg%3D%3D Occurrence Handle10.1016/S0041-1345(99)00398-X

    Article  PubMed  CAS  Google Scholar 

  18. YB Qian CL Liu CM Lo ST Fan (2004) ArticleTitleRisk factors for biliary complications after liver transplantation Arch Surg 139 1101–5 Occurrence Handle15492152 Occurrence Handle10.1001/archsurg.139.10.1101

    Article  PubMed  Google Scholar 

  19. RW Osorio CE Freise PG Stock JR Lake JM Laberge RL Gordon et al. (1993) ArticleTitleNonoperative management of biliary leaks after orthotopic liver transplantation Transplantation 55 1074–7 Occurrence Handle8497884 Occurrence Handle1:STN:280:DyaK3s3mvFaltg%3D%3D Occurrence Handle10.1097/00007890-199305000-00026

    Article  PubMed  CAS  Google Scholar 

  20. L Urbani A Campatelli J Romagnoli G Catalano G Sartoni A Costa et al. (2002) ArticleTitleT-tube removal after liver transplantation: a new technique that reduces biliary complications Transplantation 74 410–3 Occurrence Handle12177624 Occurrence Handle10.1097/00007890-200208150-00021

    Article  PubMed  Google Scholar 

  21. K Rolles G Fusai N Rolando R Koti D Patch BR Davidson et al. (2005) ArticleTitleEndoscopic biliary stenting facilitates safe and early removal of T-tube in liver transplant patients Minerva Chir 60 31–5 Occurrence Handle15902051 Occurrence Handle1:STN:280:DC%2BD2M3mtFektg%3D%3D

    PubMed  CAS  Google Scholar 

  22. V Vougas M Rela E Gane et al. (1996) ArticleTitleA prospective randomized trial of bile duct reconstruction at liver transplantation: T-tube or no T-tube? Transplant Int 9 492–5 Occurrence Handle10.1007/BF00335701

    Article  Google Scholar 

  23. O Scatton B Meunier D Cherqui O Boillot A Sauvanet K Boudjema et al. (2001) ArticleTitleRandomized trial of choledochocholedocho-stomy with or without a T-tube in orthotopic liver transplantation Ann Surg 233 432–7 Occurrence Handle11224633 Occurrence Handle1:STN:280:DC%2BD3M7ps1ektw%3D%3D Occurrence Handle10.1097/00000658-200103000-00019

    Article  PubMed  CAS  Google Scholar 

  24. T Kusano HB Randall JP Roberts NL Ascher (2005) ArticleTitleThe use of stents for duct-to-duct anastomoses of biliary reconstruction in orthotopic liver transplantation Hepatogastro-enterology 52 695–9

    Google Scholar 

  25. M Shimoda S Saab M Morrisey RM Ghobrial DG Farmer P Chen et al. (2001) ArticleTitleA cost-effectiveness analysis of biliary anastomosis with or without T-tube after orthotopic liver transplantation Am J Transplant 1 157–61 Occurrence Handle12099364 Occurrence Handle1:STN:280:DC%2BD38zls1SmtQ%3D%3D

    PubMed  CAS  Google Scholar 

  26. A Amador R Charco J Marti et al. (2005) ArticleTitleCost/efficacy clinical trial about the use of T-tube in cadaveric donor liver transplant: preliminary results Transplant Proc 37 1129–30 Occurrence Handle15848645 Occurrence Handle1:STN:280:DC%2BD2M3hsV2ruw%3D%3D Occurrence Handle10.1016/j.transproceed.2005.01.015

    Article  PubMed  CAS  Google Scholar 

  27. F Innocenti J Hepp R Humeres H Rios L Suarez R Zapata et al. (2004) ArticleTitleTranscystic cholangiogram access via rubber band with early withdrawal after liver transplantation: a safe technique Transplant Proc 36 1681–2 Occurrence Handle15350451 Occurrence Handle1:STN:280:DC%2BD2cvksVertg%3D%3D Occurrence Handle10.1016/j.transproceed.2004.06.062

    Article  PubMed  CAS  Google Scholar 

  28. AN Langnas W Marujo RJ Stratta RP Wood SJ Li BW Shaw (1991) ArticleTitleHepatic allograft rescue following arterial thrombosis Transplantation 51 86–90 Occurrence Handle1987710 Occurrence Handle1:STN:280:DyaK3M7gt1ygsA%3D%3D Occurrence Handle10.1097/00007890-199101000-00013

    Article  PubMed  CAS  Google Scholar 

  29. L Sanchez-Urdazpal GJ Gores EM Ward TP Maus HE Wahlstrom et al. (1992) ArticleTitleIschemic-type biliary complications after orthotopic liver transplantation Hepatology 16 49–53 Occurrence Handle1618482 Occurrence Handle1:STN:280:DyaK38zhs1Cruw%3D%3D

    PubMed  CAS  Google Scholar 

  30. PA Sheiner CV Varma JV Guarrera J Cooper M Garatti S Emre et al. (1997) ArticleTitleSelective revascularization of hepatic artery thromboses after liver transplantation improves patient and graft survival Transplantation 64 1295–9 Occurrence Handle9371671 Occurrence Handle1:STN:280:DyaK1c%2FjslOhsA%3D%3D Occurrence Handle10.1097/00007890-199711150-00011

    Article  PubMed  CAS  Google Scholar 

  31. BJ Stange M Glanemann NC Nuessler U Settmacher T Steinmuller P Neuhaus (2003) ArticleTitleHepatic artery thrombosis after adult liver transplantation Liver Transpl 9 612–20 Occurrence Handle12783404 Occurrence Handle10.1053/jlts.2003.50098

    Article  PubMed  Google Scholar 

  32. RW Busuttil DG Farmer H Yersiz JR Hiatt SV McDiarmid LI Goldstein et al. (2005) ArticleTitleAnalysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience Ann Surg 241 905–16 Occurrence Handle15912040 Occurrence Handle10.1097/01.sla.0000164077.77912.98

    Article  PubMed  Google Scholar 

  33. MS Abouljoud DY Kim A Yoshida J Arenas J Jerius L Malinzak et al. (2005) ArticleTitleImpact of aberrant arterial anatomy and location of anastomosis on technical outcomes after liver transplantation J Gastrointest Surg 9 672–8 Occurrence Handle15862262 Occurrence Handle10.1016/j.gassur.2005.01.002

    Article  PubMed  Google Scholar 

  34. WE Saad NE Saad MG Davies DE Lee NC Patel LG Sahler et al. (2005) ArticleTitleTranshepatic balloon dilation of anastomotic biliary strictures in liver transplant recipients: the significance of a patent hepatic artery J Vasc Interv Radiol 16 1221–8 Occurrence Handle16151063

    PubMed  Google Scholar 

  35. NC Nuessler U Settmacher R Haase B Stange M Heise P Neuhaus (2003) ArticleTitleDiagnosis and treatment of arterial steal syndromes in liver transplant recipients Liver Transpl 9 596–602 Occurrence Handle10.1053/jlts.2003.50080

    Article  Google Scholar 

  36. MA Moser WJ Wall (2001) ArticleTitleManagement of biliary problems after liver transplantation Liver Transpl 7 IssueID11 Suppl 2 S46–52 Occurrence Handle11689776 Occurrence Handle1:STN:280:DC%2BD3MnktVShsA%3D%3D Occurrence Handle10.1053/jlts.2001.28518

    Article  PubMed  CAS  Google Scholar 

  37. G Testa M Malago CE Broelsch (2001) ArticleTitleComplications of biliary tract in liver transplantation World J Surg 25 1296–9 Occurrence Handle11596893 Occurrence Handle1:STN:280:DC%2BD3MrltVKqsw%3D%3D Occurrence Handle10.1007/s00268-001-0113-5

    Article  PubMed  CAS  Google Scholar 

  38. HG Hendriks J van der Meer JT de Wolf PM Peeters RJ Porte K De Jong et al. (2005) ArticleTitleIntraoperative blood transfusion requirement is the main determinant of early surgical re-intervention after orthotopic liver transplantation Transpl Int 17 673–9 Occurrence Handle15717214 Occurrence Handle1:STN:280:DC%2BD2M7hsVaitw%3D%3D Occurrence Handle10.1007/s00147-004-0793-5

    Article  PubMed  CAS  Google Scholar 

  39. N Nakamura S Nishida GR Neff A Vaidya DM Levi T Kato et al. (2005) ArticleTitleIntrahepatic biliary strictures without hepatic artery thrombosis after liver transplantation: an analysis of 1113 liver transplantations at a single center Transplantation 79 427–32 Occurrence Handle15729168 Occurrence Handle10.1097/01.TP.0000152800.19986.9E

    Article  PubMed  Google Scholar 

  40. JO Colonna A Shaked AS Gomes SD Colquhoun O Jurim SV McDiarmid et al. (1992) ArticleTitleBiliary strictures complicating liver transplantation. Incidence, pathogenesis, management, and outcome Ann Surg 216 344–50 Occurrence Handle1417184 Occurrence Handle10.1097/00000658-199209000-00014

    Article  PubMed  Google Scholar 

  41. L Sanchez-Urdazpal GJ Gores EM Ward TP Maus EG Buckel et al. (1993) ArticleTitleDiagnostic features and clinical outcome of ischemic-type biliary complications after liver transplantation Hepatology 17 605–9 Occurrence Handle8477965 Occurrence Handle1:STN:280:DyaK3s3jvFWisg%3D%3D

    PubMed  CAS  Google Scholar 

  42. A Fisher CM Miller (1995) ArticleTitleIschemic-type biliary strictures in liver allografts: the Achilles heel revisited? Hepatology 21 589–91 Occurrence Handle7843733 Occurrence Handle1:STN:280:DyaK2M7ks1SltQ%3D%3D Occurrence Handle10.1016/0270-9139(95)90123-X

    Article  PubMed  CAS  Google Scholar 

  43. HJ Schlitt PN Meier B Nashan J Oldhaferk K Boekey P Flemming et al. (1999) ArticleTitleReconstructive surgery for ischemic-type lesions at the bile duct bifurcation after liver transplantation Ann Surg 229 137–45 Occurrence Handle9923811 Occurrence Handle1:STN:280:DyaK1M7itVKrtA%3D%3D Occurrence Handle10.1097/00000658-199901000-00018

    Article  PubMed  CAS  Google Scholar 

  44. RE Hintze A Adler W Veltzke H Abou-Rebyeh R Felix P Neuhaus (1997) ArticleTitleEndoscopic management of biliary complications after orthotopic liver transplantation Hepatogastroenterology 44 258–62 Occurrence Handle9058155 Occurrence Handle1:STN:280:DyaK2s3htFWmtQ%3D%3D

    PubMed  CAS  Google Scholar 

  45. M Scotte B Dousset Y Calmus F Conti D Houssin Y Chapuis (1994) ArticleTitleThe influence of cold ischemia time on biliary complications following liver transplantation J Hepatol 21 340–6 Occurrence Handle7836702 Occurrence Handle1:STN:280:DyaK2M7jvVCmtQ%3D%3D Occurrence Handle10.1016/S0168-8278(05)80311-3

    Article  PubMed  CAS  Google Scholar 

  46. C Moench K Moench AW Lohse J Thies G Otto (2003) ArticleTitlePrevention of ischemic-type biliary lesions by arterial back-table pressure perfusion Liver Transpl 9 285–9 Occurrence Handle12619026 Occurrence Handle10.1053/jlts.2003.50015

    Article  PubMed  Google Scholar 

  47. WG Polak S Miyamoto BA Nemes PM Peeters KP de Jong RJ Porte et al. (2005) ArticleTitleSequential and simultaneous revascularization in adult orthotopic piggyback liver transplantation Liver Transpl 11 934–40 Occurrence Handle16035059 Occurrence Handle10.1002/lt.20513

    Article  PubMed  Google Scholar 

  48. S Kakizoe K Yanaga TE Starzl AJ Demetris (1990) ArticleTitleEvaluation of protocol before transplantation and after reperfusion biopsies from human orthotopic liver allografts: considerations of preservation and early immunological injury Hepatology 11 932–41 Occurrence Handle2365291 Occurrence Handle1:STN:280:DyaK3czgs12isg%3D%3D

    PubMed  CAS  Google Scholar 

  49. J Busquets J Figueras T Serrano J Torras E Ramos A Rafecas et al. (2001) ArticleTitlePostreperfusion biopsies are useful in predicting complications after liver transplantation Liver Transpl 7 432–5 Occurrence Handle11349264 Occurrence Handle1:STN:280:DC%2BD3MvjsFOkug%3D%3D Occurrence Handle10.1053/jlts.2001.23868

    Article  PubMed  CAS  Google Scholar 

  50. L Sanchez-Urdazpal KP Batts GJ Gores SB Moore S Sterioff et al. (1993) ArticleTitleIncreased bile duct complications in liver transplantations across the ABO barrier Ann Surg 218 152–8 Occurrence Handle8342994 Occurrence Handle1:STN:280:DyaK3szktlKrsA%3D%3D Occurrence Handle10.1097/00000658-199308000-00006

    Article  PubMed  CAS  Google Scholar 

  51. CM Lo A Shaked RW Busuttil (1994) ArticleTitleRisk factors for liver transplantation across the ABO barrier Transplantation 58 543–7 Occurrence Handle8091480 Occurrence Handle1:STN:280:DyaK2cznvVaqsQ%3D%3D Occurrence Handle10.1097/00007890-199409000-00003

    Article  PubMed  CAS  Google Scholar 

  52. J Ludwig RH Wiesner KP Batts JD Perkins RA Krom (1987) ArticleTitleAcute vanishing bile duct syndrome (acute irreversible rejection) after orthotopic liver transplantation Hepatology 7 476–83 Occurrence Handle3552923 Occurrence Handle1:STN:280:DyaL2s7pt1CksA%3D%3D

    PubMed  CAS  Google Scholar 

  53. IW Graziadei (2002) ArticleTitleRecurrence of primary sclerosing cholangitis after liver transplantation Liver Transpl 8 575–81 Occurrence Handle12089708 Occurrence Handle10.1053/jlts.2002.33952

    Article  PubMed  Google Scholar 

  54. JA Goss CR Shackleton DG Farmer WS Arnaout P Seu JS Markowitz et al. (1997) ArticleTitleOrthotopic liver transplantation for primary sclerosing cholangitis. A 12-year single center experience Ann Surg 225 472–83 Occurrence Handle9193175 Occurrence Handle1:STN:280:DyaK2szjs1Chtg%3D%3D Occurrence Handle10.1097/00000658-199705000-00004

    Article  PubMed  CAS  Google Scholar 

  55. IW Graziadei RH Wiesner PJ Marottta MK Porayko JE Hay MR Charlton (1999) ArticleTitleLong-term results of patients undergoing liver transplantation for primary sclerosing cholangitis Hepatology 30 1121–7 Occurrence Handle10534330 Occurrence Handle1:STN:280:DC%2BD3c%2FgsVGqug%3D%3D Occurrence Handle10.1002/hep.510300501

    Article  PubMed  CAS  Google Scholar 

  56. A Vera S Moledina B Gunson S Hubscher D Mirza S Olliff et al. (2002) ArticleTitleRisk factors for recurrence of primary sclerosing cholangitis of liver allograft Lancet 360 1943–4 Occurrence Handle12493264 Occurrence Handle10.1016/S0140-6736(02)11861-7

    Article  PubMed  Google Scholar 

  57. MM Guichelaar JT Benson M Malinchoc RA Krom RH Wiesher MR Charlton (2003) ArticleTitleRisk factors for and clinical course of non-anastomotic biliary strictures after liver transplantation Am J Transplant 3 885–90 Occurrence Handle12814481 Occurrence Handle10.1034/j.1600-6143.2003.00165.x

    Article  PubMed  Google Scholar 

  58. C Moench A Uhrig AW Lohse G Otto (2004) ArticleTitleCC chemokine receptor 5 delta 32 polymorphism — a risk factor for ischemic-type biliary lesions following orthotopic liver transplantation Liver Transpl 10 434–9 Occurrence Handle15004773 Occurrence Handle10.1002/lt.20095

    Article  PubMed  Google Scholar 

  59. JO Colonna (1996) Technical problems: biliary R Busuttil G Klintmalm (Eds) Transplantation of the liver, First edn W B Saunders Philadelphia 617–25

    Google Scholar 

  60. M Sebagh F Yilmaz V Karam B Falissard B Roche D Azoulay et al. (2005) ArticleTitleThe histologic pattern of “biliary tract pathology” is accurate for the diagnosis of biliary complications Am J Surg Pathol 29 318–23 Occurrence Handle15725799 Occurrence Handle10.1097/01.pas.0000152139.66524.ab

    Article  PubMed  Google Scholar 

  61. JW Ostroff (2001) ArticleTitlePosttransplant biliary problems Gastrointest Endosc Clin North Am 11 163–83 Occurrence Handle1:STN:280:DC%2BD3M3itlKjsA%3D%3D

    CAS  Google Scholar 

  62. J Ludwig KP Batts RL MacCarty (1992) ArticleTitleIschemic cholangitis in hepatic allografts Mayo Clin Proc 67 519–26 Occurrence Handle1434878 Occurrence Handle1:STN:280:DyaK3s%2FmtFegug%3D%3D

    PubMed  CAS  Google Scholar 

  63. M Sebagh K Rifai C Feray F Yilmaz B Falissard B Roche et al. (2003) ArticleTitleAll liver recipients benefit from the protocol 10-year liver biopsies Hepatology 37 1293–301 Occurrence Handle12774007 Occurrence Handle10.1053/jhep.2003.50231

    Article  PubMed  Google Scholar 

  64. T Zoepf EJ Maldonado-Lopez P Hilgard A Dechene M Malago CE Broelsch et al. (2005) ArticleTitleDiagnosis of biliary strictures after liver transplantation: which is the best tool? World J Gastroenterol 11 2945–8 Occurrence Handle15902733

    PubMed  Google Scholar 

  65. SV McDiarmid TR Hall EG Grant AL Milewicz K Olthoff J Lois et al. (1991) ArticleTitleFailure of duplex sonography to diagnose hepatic artery thrombosis in a high risk group of pediatric liver transplant recipients J Pediatr Surg 26 710–3 Occurrence Handle1941463 Occurrence Handle1:STN:280:DyaK38%2FksFamsg%3D%3D Occurrence Handle10.1016/0022-3468(91)90016-M

    Article  PubMed  CAS  Google Scholar 

  66. S Quiroga MC Sebastia C Margarit L Castells R Boye A Alvarez-Castells (2001) ArticleTitleComplications of orthotopic liver transplantation: spectrum of findings with helical CT Radiographics 21 1085–102 Occurrence Handle11553818 Occurrence Handle1:STN:280:DC%2BD3Mrhs1Sqsw%3D%3D

    PubMed  CAS  Google Scholar 

  67. YF Cheng TY Lee CL Chen TL Huang YS Chen CC Lui (1997) ArticleTitleThree-dimensional helical computed tomographic cholangiography: application to living related hepatic transplantation Clin Transplant 11 209–13 Occurrence Handle9193844 Occurrence Handle1:STN:280:DyaK2szjslWjsA%3D%3D

    PubMed  CAS  Google Scholar 

  68. HJ O'Connor CR Vickers JA Buckels P McMaster JM Neuberger RJ West et al. (1991) ArticleTitleRole of endoscopic retrograde cholangiopancreatography after orthotopic liver transplantation Gut 32 419–23 Occurrence Handle2026341

    PubMed  Google Scholar 

  69. S Sherman P Jamidar A Shaked BJ Kendall LI Goldstein RW Busuttil (1995) ArticleTitleBiliary tract complications after orthotopic liver transplantation. Endoscopic approach to diagnosis and therapy Transplantation 60 467–70 Occurrence Handle7676495 Occurrence Handle1:STN:280:DyaK2Mvgs12nsQ%3D%3D Occurrence Handle10.1097/00007890-199509000-00011

    Article  PubMed  CAS  Google Scholar 

  70. R Shah J Dooley R Agarwal D Patch AK Burroughs K Rolles et al. (2002) ArticleTitleRoutine endoscopic retrograde cholangiography in the detction of early biliary complications after liver transplantation Liver Transpl 8 491–4 Occurrence Handle12004351 Occurrence Handle10.1053/jlts.2002.32718

    Article  PubMed  Google Scholar 

  71. KI Norton JS Lee D Kogan RB Glass BL Shneider GP Rodriguez-Laiz et al. (2001) ArticleTitleThe role of magnetic resonance cholangiography in the management of children and young adults after liver transplantation Pediatr Transplant 5 410–8 Occurrence Handle11765725 Occurrence Handle1:STN:280:DC%2BD38%2FjslGqtg%3D%3D

    PubMed  CAS  Google Scholar 

  72. JA Soto MA Barish EK Yucel JT Ferrucci (1995) ArticleTitleMR cholangiopancreatography: findings on 3D fast spinecho imaging AJR Am J Roentgenol 165 1397–401 Occurrence Handle7484573 Occurrence Handle1:STN:280:DyaK28%2Fnt1Krtw%3D%3D

    PubMed  CAS  Google Scholar 

  73. C Reinhold PM Bret (1996) ArticleTitleCurrent status of MR cholangiopancreatography AJR Am J Roentgenol 166 1285–95 Occurrence Handle8633434 Occurrence Handle1:STN:280:DyaK283it1Krug%3D%3D

    PubMed  CAS  Google Scholar 

  74. CD Becker M Grossholz G Mentha R de Peyer F Terrier (1997) ArticleTitleMR cholangiopancreatography: technique, potential indications, and diagnostic features of benign, postoperative, and malignant conditions Eur Radiol 7 865–74 Occurrence Handle9228102 Occurrence Handle1:STN:280:DyaK2szntlKntw%3D%3D Occurrence Handle10.1007/s003300050220

    Article  PubMed  CAS  Google Scholar 

  75. AS Fulcher MA Turner (1999) ArticleTitleOrthotopic liver transplantation: evaluation with MR cholangiography Radiology 211 715–22 Occurrence Handle10352596 Occurrence Handle1:STN:280:DyaK1M3otVylsA%3D%3D

    PubMed  CAS  Google Scholar 

  76. A Laghi P Pavone C Catalano M Rossi V Panebianco D Alfani et al. (1999) ArticleTitleMR cholangiography of late biliary complications after liver transplantation AJR Am J Roentgenol 172 1541–6 Occurrence Handle10350286 Occurrence Handle1:STN:280:DyaK1M3nslOruw%3D%3D

    PubMed  CAS  Google Scholar 

  77. V Meersschaut KJ Mortele R Troisi H Van Vlierberghe M De Vos L Defreyne et al. (2000) ArticleTitleValue of MR cholangiography in the evaluation of postoperative biliary complications following orthotopic liver transplantation Eur Radiol 10 1576–81 Occurrence Handle11044927 Occurrence Handle1:STN:280:DC%2BD3crgtVOiuw%3D%3D Occurrence Handle10.1007/s003300000379

    Article  PubMed  CAS  Google Scholar 

  78. R Ott H Greess U Aichinger F Fellner C Herold S Yedibela et al. (2002) ArticleTitleClinical value of MRC in the follow-up of liver transplant patients with a choledochojejunostomy Abdom Imaging 27 336–43 Occurrence Handle12173367 Occurrence Handle1:STN:280:DC%2BD38vhvVGqtg%3D%3D

    PubMed  CAS  Google Scholar 

  79. P Boraschi F Donati R Gigoni L Urbani M Femia MC Cossu et al. (2004) ArticleTitleIschemic-type biliary lesions in liver transplant recipients: evaluation with magnetic resonance cholangiography Transplant Proc 36 2744–7 Occurrence Handle15621138 Occurrence Handle1:STN:280:DC%2BD2cnksFOntQ%3D%3D Occurrence Handle10.1016/j.transproceed.2004.09.038

    Article  PubMed  CAS  Google Scholar 

  80. C Valls E Alba M Cruz J Figueras E Andia A Sanchez et al. (2005) ArticleTitleBiliary complications after liver transplantation: diagnosis with MR cholangiopancreatography AJR Am J Roentgenol 184 812–20 Occurrence Handle15728602

    PubMed  Google Scholar 

  81. P Boraschi F Donati A Volpi G Campori (2005) ArticleTitleOn the AJR viewbox. Intrapancreatic accessory spleen: diagnosis with RES-specific contrast-enhanced MRI AJR Am J Roentgenol 184 1712–3 Occurrence Handle15855152

    PubMed  Google Scholar 

  82. C Margarit E Hidalgo JL Lázaro E Murio R Charco J Balsells (1998) ArticleTitleBiliary complications secondary to late hepatic artery thrombosis in adult liver transplant patients Transpl Int 11 IssueIDSuppl 1 S251–4 Occurrence Handle9664990 Occurrence Handle10.1007/s001470050472

    Article  PubMed  Google Scholar 

  83. RJ Stratta RP Wood AN Langnas RR Hollins KJ Bruder JP Donovan et al. (1989) ArticleTitleDiagnosis and treatment of biliary tract complications after orthotopic liver transplantation Surgery 106 675–84 Occurrence Handle2799642 Occurrence Handle1:STN:280:DyaK3c%2FhvF2ltw%3D%3D

    PubMed  CAS  Google Scholar 

  84. TD Johnston R Gates KS Reddy NJ Nickl D Ranjan (2000) ArticleTitleNonoperative management of bile leaks following liver transplantation Clin Transpl 14 365–9 Occurrence Handle1:STN:280:DC%2BD3M%2FntlWnsQ%3D%3D Occurrence Handle10.1034/j.1399-0012.2000.14040102.x

    Article  CAS  Google Scholar 

  85. AS Klien S Savader JP Burdick S Fair M Mitchell P Colombani et al. (1991) ArticleTitleReduction of morbidity and mortality from biliary complications after liver transplantation Hepatology 14 818–23

    Google Scholar 

  86. R Sheng JK Sammon AB Zajko WL Campbell (1994) ArticleTitleBile leak after hepatic transplantation: cholangiographic features, prevalence, and clinical outcome Radiology 192 413–6 Occurrence Handle8029406 Occurrence Handle1:STN:280:DyaK2czgt1ahtQ%3D%3D

    PubMed  CAS  Google Scholar 

  87. DJ Verran SK Asfar CN Ghent DR Grant WJ Wall (1997) ArticleTitleBiliary reconstruction without T-tubes or stents in liver transplantation: report of 502 consecutive cases Liver Transpl Surg 3 365–73 Occurrence Handle9346765 Occurrence Handle1:STN:280:DyaK1c%2Fgtlertg%3D%3D Occurrence Handle10.1002/lt.500030403

    Article  PubMed  CAS  Google Scholar 

  88. RS Brown MW Russo M Lai ML Shiffman MC Richardson JE Everhart et al. (2003) ArticleTitleA survey of liver transplantation from living adult donors in the United States N Engl J Med 348 818–25 Occurrence Handle12606737 Occurrence Handle10.1056/NEJMsa021345

    Article  PubMed  Google Scholar 

  89. Y Sugawara M Makuuchi K Sano T Ohkubo J Kaneko T Takayama (2002) ArticleTitleDuct-to-duct biliary reconstruction in living-related liver transplantation Transplantation 73 1348–50 Occurrence Handle11981435 Occurrence Handle10.1097/00007890-200204270-00029

    Article  PubMed  Google Scholar 

  90. U Settmacher Steinmueller Th SC Schmidt M Heise A Pascher T Theruvath et al. (2003) ArticleTitleTechnique of bile duct reconstruction and management of biliary complications in right lobe living donor liver transplantation Clin Transplant 17 37–42 Occurrence Handle12588320 Occurrence Handle1:STN:280:DC%2BD3s7htFyisQ%3D%3D Occurrence Handle10.1034/j.1399-0012.2003.02058.x

    Article  PubMed  CAS  Google Scholar 

  91. G Testa M Malagó C Valentin-Gamazo G Lindell CE Broelsch (2000) ArticleTitleBiliary anastomosis in living related liver transplantation using the right liver lobe: techniques and complications Liver Transpl 6 710–4 Occurrence Handle11084056 Occurrence Handle1:STN:280:DC%2BD3M%2FmtlGjtA%3D%3D Occurrence Handle10.1053/jlts.2000.18706

    Article  PubMed  CAS  Google Scholar 

  92. RS Rizk JP McVicar MJ Edmond CA Rohrmann SuffixJr KV Kowdrey J Perkins et al. (1998) ArticleTitleEndoscopic management of biliary strictures in liver transplant recipients; effect on patient and graft survival Gastrointest Endosc 47 128–35 Occurrence Handle9512276 Occurrence Handle1:STN:280:DyaK1c7ntFagsg%3D%3D Occurrence Handle10.1016/S0016-5107(98)70344-X

    Article  PubMed  CAS  Google Scholar 

  93. N Bourgeois J Deviere P Yeaton F Bourgeois M Adler J Van De Stadt et al. (1995) ArticleTitleDiagnostic and therapeutic endoscopic retrograde cholangiography after liver transplantation Gastrointest Endosc 42 527–34 Occurrence Handle8674922 Occurrence Handle1:STN:280:DyaK283jsFyhuw%3D%3D Occurrence Handle10.1016/S0016-5107(95)70005-6

    Article  PubMed  CAS  Google Scholar 

  94. AF Rossi C Grosso G Zanasi P Gambitta M Bini L De Carlis et al. (1998) ArticleTitleLong-term efficacy of endoscopic stenting in patients with stricture of the biliary anastomosis after orthotopic liver transplantation Endoscopy 30 360–6 Occurrence Handle9689509 Occurrence Handle1:STN:280:DyaK1czltl2gtg%3D%3D Occurrence Handle10.1055/s-2007-1001283

    Article  PubMed  CAS  Google Scholar 

  95. S Mosca G Militerno MA Guardascione L Amitrano FP Picciotto O Cuomo (2000) ArticleTitleLate biliary tract complications after orthotopic liver transplantation: diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography J Gastroenterol Hepatol 15 654–60 Occurrence Handle10921420 Occurrence Handle1:STN:280:DC%2BD3M%2FjsFSisw%3D%3D Occurrence Handle10.1046/j.1440-1746.2000.02198.x

    Article  PubMed  CAS  Google Scholar 

  96. RV Mahajani SJ Cotler F Uzor (2000) ArticleTitleEfficacy of endoscopic management of anastomotic biliary strictures after liver transplantation Endoscopy 32 843–9 Occurrence Handle10.1055/s-2000-9619

    Article  Google Scholar 

  97. DA Schwartz BT Pettersen JJ Poterucha CJ Gostont (2000) ArticleTitleEndoscopic therapy of anastomotic bile duct strictures occurring after liver transplantation Gastrointest Endosc 51 169–74 Occurrence Handle10650259 Occurrence Handle1:STN:280:DC%2BD3c7hslOmuw%3D%3D Occurrence Handle10.1016/S0016-5107(00)70413-5

    Article  PubMed  CAS  Google Scholar 

  98. JR Lake (1995) ArticleTitleLong-term management of biliary tract complications Liver Transpl Surg 1 45–54 Occurrence Handle9346600 Occurrence Handle1:STN:280:DyaK1c%2Fgtlajtg%3D%3D Occurrence Handle10.1002/lt.500010414

    Article  PubMed  CAS  Google Scholar 

  99. BD Petersen SR Maxfield K Ivancev BT Uchida JM Rabkin J Rosch (1996) ArticleTitleBiliary strictures in hepatic transplantation: treatment with self-expanding Z stents J Vasc Interv Radiol 7 221–8 Occurrence Handle9007801 Occurrence Handle1:STN:280:DyaK2s7mtVartw%3D%3D Occurrence Handle10.1016/S1051-0443(96)70765-0

    Article  PubMed  CAS  Google Scholar 

  100. O Guckelberger B Stange M Glanemann E Lopez-Hanninen C Heidenhaih S Jonas et al. (2005) ArticleTitleHepatic resection in liver transplant recipients: single center experience and review of the literature Am J Transplant 5 2403–9 Occurrence Handle16162188 Occurrence Handle10.1111/j.1600-6143.2005.01032.x

    Article  PubMed  Google Scholar 

  101. A Pascher P Neuhaus (2005) ArticleTitleBile duct complications after liver transplantation Transpl Int 18 627–42 Occurrence Handle15910286 Occurrence Handle10.1111/j.1432-2277.2005.00123.x

    Article  PubMed  Google Scholar 

  102. DV Gopal PR Pfau MR Lucey (2003) ArticleTitleEndoscopic management of biliary complications after orthotopic liver transplantation Curr Treat Options Gastroenterol 6 509–15 Occurrence Handle14585240

    PubMed  Google Scholar 

  103. J Neuberger (2003) ArticleTitleLiver transplantation for cholestatic liver disease Curr Treat Options Gastroenterol 6 113–21 Occurrence Handle12628070

    PubMed  Google Scholar 

  104. B Brandsaeter H Isoniemi U Broome M Olausson L Backman B Hasen et al. (2004) ArticleTitleLiver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy J Hepatol 40 815–22 Occurrence Handle15094230 Occurrence Handle1:STN:280:DC%2BD2c3osl2mug%3D%3D Occurrence Handle10.1016/j.jhep.2004.01.002

    Article  PubMed  CAS  Google Scholar 

  105. PA Clavien Ca Camargo L Bailile JG Fitz (1995) ArticleTitleSphincter of Oddi dysfunction after liver transplantation Dig Dis Sci 40 73–4 Occurrence Handle7821122 Occurrence Handle1:STN:280:DyaK2M7itFWjtA%3D%3D Occurrence Handle10.1007/BF02063944

    Article  PubMed  CAS  Google Scholar 

  106. V Douzdjian MM Abecassis FC Johlin (1994) ArticleTitleSphincter of Oddi dysfunction following liver transplantation Dig Dis Sci 39 253–6 Occurrence Handle8313805 Occurrence Handle1:STN:280:DyaK2c7kslyrtw%3D%3D Occurrence Handle10.1007/BF02090194

    Article  PubMed  CAS  Google Scholar 

  107. R Sheng CB Ramirez AB Zajko WL Campbell (1996) ArticleTitleBiliary stones and sludge in liver transplant patients: a 13-year experience Radiology 198 243–7 Occurrence Handle8539387 Occurrence Handle1:STN:280:DyaK287itlWktw%3D%3D

    PubMed  CAS  Google Scholar 

  108. TE Starzl CW Putnam JF Hansbrough et al. (1997) ArticleTitleBiliary complications after liver transplantation: with special reference to the biliary cast syndrome and techniques of secondary duct repair Surgery 81 212–21

    Google Scholar 

  109. M Farouk GD Branum CR Walters et al. (1991) ArticleTitleBile compositional changes and cholesterol stone formation following orthotopic liver transplantation Transplantation 52 727–30 Occurrence Handle1926353 Occurrence Handle1:STN:280:DyaK38%2FitlGmsA%3D%3D Occurrence Handle10.1097/00007890-199110000-00028

    Article  PubMed  CAS  Google Scholar 

  110. C Manzarbeitia J Jonsson V Rustgi VK Oyloe L Olson L Hefter et al. (1993) ArticleTitleManagement of hemobilia after liver biopsy in liver transplant recipients Transplantation 56 1545–7 Occurrence Handle8279035 Occurrence Handle1:STN:280:DyaK2c7gs1SjtQ%3D%3D

    PubMed  CAS  Google Scholar 

  111. J Pitre B Dousset P Massault O Soubrane P Legmann D Houssin (1997) ArticleTitleMultiple intrahepatic stones caused by hemobilia in liver transplant recipients Surgery 121 352–4 Occurrence Handle9068678 Occurrence Handle1:STN:280:DyaK2s3itFKgsA%3D%3D Occurrence Handle10.1016/S0039-6060(97)90365-2

    Article  PubMed  CAS  Google Scholar 

  112. M Lang U Neumann AR Mueller WO Bechstein R Neuhaus P Neuhaus (1999) ArticleTitleComplications of percutaneous liver biopsy in patients after liver transplantation Z Gastroenterol 37 205–8 Occurrence Handle10234792 Occurrence Handle1:STN:280:DyaK1M3ltFWjsg%3D%3D

    PubMed  CAS  Google Scholar 

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Pascher, A., Neuhaus, P. Biliary complications after deceased-donor orthotopic liver transplantation. J Hepatobiliary Pancreat Surg 13, 487–496 (2006). https://doi.org/10.1007/s00534-005-1083-z

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