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Effect of spasmolytic drugs on esophageal foreign bodies

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Abstract

Muscle spasm has been proposed as the cause for esophageal food impaction. The aim was therefore to treat esophageal foreign bodies with spasmolytic drugs influencing both striated and smooth muscles of the esophagus. A multicenter, placebo-controlled, doubleblind study of glucagon and diazepam was undertaken in 43 patients. The foreign body disimpacted in 9 of 24 patients given active substances and in 6 of 19 patients given placebo; there was no significant difference between these two groups. Almost all disimpactions occurred several hours after injection of the drugs. The hypothesis of muscle spasm as an important cause of esophageal obstruction was rejected. Medical therapies for food disimpaction other than spasmolytic drugs have to be investigated.

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Authors and Affiliations

  1. ENT-department of the University Hospital in Linköping, Sweden

    Lita Tibbling MD, PhD

  2. ENT-department of the University Hospital in Uppsala, Sweden

    Monika Stenkvist

  3. the central hospital of Jönköping, Sweden

    Anders Bjorkhoel

  4. the central hospital of Norrköping, Sweden

    Elisabeth Jansson

Authors
  1. Lita Tibbling MD, PhD
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  2. Anders Bjorkhoel
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  3. Elisabeth Jansson
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  4. Monika Stenkvist
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Tibbling, L., Bjorkhoel, A., Jansson, E. et al. Effect of spasmolytic drugs on esophageal foreign bodies. Dysphagia 10, 126–127 (1995). https://doi.org/10.1007/BF00440084

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  • DOI: https://doi.org/10.1007/BF00440084

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