Variables | High NFS* | Low or Med NFS† | Probability | Overall NAFLD cohort |
Demographic data | ||||
N | 129 | 2386 | 2515 | |
Age, years | 62.78±11.09 | 47.96±15.33 | 0.0000 | 48.72±15.48 |
Race | ||||
White | 59 (45.7%) | 838 (35.1%) | 0.0142 | 897 (35.7%) |
Black | 39 (30.2%) | 506 (21.2%) | 0.0154 | 545 (21.7%) |
Hispanic | 26 (20.2%) | 951 (39.9%) | 0.0000 | 977 (38.8%) |
Male | 42 (32.6%) | 1166 (48.9%) | 0.0003 | 1208 (48.0%) |
Clinical data | ||||
BMI | 37.304±9.395 | 30.214±6.274 | 0.0000 | 30.577±6.654 |
Waist circumference, cm | 116.884±16.416 | 101.322±14.853 | 0.0000 | 102.097±15.310 |
Obesity | 100 (77.5%) | 1115 (46.7%) | 0.0000 | 1215 (48.3%) |
Glucose, mg/dL | 165.429±91.884 | 112.727±51.749 | 0.0000 | 115.434±55.734 |
Insulin | 27.552±21.139 | 18.164± +/-19.834 | 0.0000 | 18.649±20.007 |
Homeostasis Model Assessment | 12.337±14.440 | 5.670±11.023 | 0.0000 | 6.015±11.318 |
Total cholesterol, mg/dL | 214.674±49.724 | 212.407±45.646 | 0.8328 | 212.523±45.856 |
HDL, mg/dL | 47.685±20.348 | 45.458±13.973 | 0.5940 | 45.571±14.369 |
LDL, mg/dL | 120.212±33.238 | 130.079±37.888 | 0.1113 | 129.564±37.708 |
Hypercholesterolaemia | 108 (83.7%) | 1968 (82.5%) | 0.7179 | 2076 (82.5%) |
Triglyceride, mg/dL | 222.233±186.609 | 195.818±141.821 | 0.1597 | 197.173±144.529 |
AST, IU/L | 29.512±31.733 | 24.363±15.737 | 0.6044 | 24.627±16.956 |
ALT, IU/L | 18.318±14.758 | 24.006±21.072 | 0.0000 | 23.714±20.830 |
Elevated liver enzymes | 27 (20.9%) | 404 (16.9%) | 0.2405 | 431 (17.1%) |
Serum albumin, g/dL | 3.864±0.356 | 4.144±0.365 | 0.0000 | 4.129±0.370 |
Platelet count, ×109 | 203.589±55.424 | 283.519±71.018 | 0.0000 | 279.419±72.472 |
Hypertension | 84 (65.1%) | 864 (36.2%) | 0.0000 | 948 (37.7%) |
Diabetes | 97 (75.2%) | 421 (17.6%) | 0.0000 | 518 (20.6%) |
Metabolic syndrome | 76 (80.0%) | 1153 (55.5%) | 0.0000 | 1229 (56.6%) |
CHF | 18 (14.2%) | 90 (3.8%) | 0.0000 | 108 (4.3%) |
Stroke | 9 (7.0%) | 62 (2.6%) | 0.0035 | 71 (2.8%) |
Smoking | 18 (14.0%) | 512 (21.5%) | 0.0416 | 530 (21.1%) |
Non-Alcoholic Fatty Liver Score | 1.536±0.836 | −2.079±1.399 | 0.0000 | −1.894±1.590 |
Mortality data | ||||
Months of follow-up | 151.357±78.005 | 210.950±56.808 | 0.0000 | 207.891±59.535 |
Die | 87 (67.4%) | 667 (28.0%) | 0.0000 | 754 (30.0%) |
*High NFS defined as NFS >0.676.
†Low or medium NFS defined as NFS ≤0.676.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CHF, congestive heart failure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD Fibrosis Score; NHANES III, National Health and Nutrition Examination Survey.