Predictors | aHR | 95% CI | P value |
NFS as a continuous predictor | |||
NFS | 1.062 | 0.997 to 1.131 | 0.0599 |
Age, years | 1.076 | 1.067 to 1.084 | <0.0001 |
Male | 1.424 | 1.228 to 1.65 | <0.0001 |
Black | 1.236 | 1.035 to 1.476 | 0.0193 |
Hypertension | 1.398 | 1.196 to 1.635 | <0.0001 |
Diabetes | 1.709 | 1.44 to 2.028 | <0.0001 |
CHF | 1.781 | 1.391 to 2.279 | <0.0001 |
Stroke | 1.845 | 1.374 to 2.478 | <0.0001 |
Smoking | 1.748 | 1.471 to 2.076 | <0.0001 |
Conventional NFS thresholds for high and low | |||
High NFS | 1.372 | 1.073 to 1.755 | 0.0118 |
Low NFS | 0.917 | 0.768 to 1.096 | 0.3407 |
Age, years | 1.077 | 1.069 to 1.085 | <0.0001 |
Male | 1.441 | 1.242 to 1.672 | <0.0001 |
Black | 1.242 | 1.042 to 1.481 | 0.0156 |
Hypertension | 1.404 | 1.201 to 1.642 | <0.0001 |
Diabetes | 1.694 | 1.433 to 2.003 | <0.0001 |
CHF | 1.768 | 1.382 to 2.261 | <0.0001 |
Stroke | 1.845 | 1.376 to 2.475 | <0.0001 |
Smoking | 1.741 | 1.467 to 2.067 | <0.0001 |
Best NFS threshold of 0.8 | |||
NFS (0.8) | 1.411 | 1.085 to 1.834 | 0.0102 |
Age, years | 1.078 | 1.071 to 1.086 | <0.0001 |
Male | 1.438 | 1.241 to 1.667 | <0.0001 |
Black | 1.251 | 1.05 to 1.49 | 0.0121 |
Hypertension | 1.406 | 1.202 to 1.644 | <0.0001 |
Diabetes | 1.745 | 1.487 to 2.047 | <0.0001 |
CHF | 1.783 | 1.394 to 2.282 | <0.0001 |
Stroke | 1.872 | 1.396 to 2.509 | <0.0001 |
Smoking | 1.738 | 1.465 to 2.064 | <0.0001 |
Adjusted HRs were calculated using Cox proportional hazard model.
CHF, congestive heart failure; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD Fibrosis Score; NHANES III, National Health and Nutrition Examination Survey.