Microbiota alterations in colon cancer mucosa and tumour samples compared with non-cancer control mucosa at colonoscopy
| Phylum | Genus | Relative abundance (%) | ||||
|---|---|---|---|---|---|---|
| Colon cancer | Mucosa vs control, p value (FDR) | Tumour vs control, p value (FDR) | ||||
| Control (n=14) | Mucosa (n=12) | Tumour (n=12) | ||||
| Actinobacteria | Coriobacteriaceae spp | 0.25±0.46 | 0.38±0.23 | 0.30±0.25 | 0.04 (0.1) | – |
| Bacteroidetes | Rikenellaceae spp | 0.03±0.06 | 0.36±0.55 | 0.29±0.60 | 0.004 (0.05) | 0.009 (0.07) |
| Prevotella | 5.1±16 | 5.1±9.2 | 4.4±8.7 | – | 0.01 (0.09) | |
| Odoribacter | 0.08±0.13 | 0.18±0.18 | 0.16±0.20 | 0.04 (0.1) | – | |
| [Barnesiellaceae] spp | 0.17±0.35 | 0.33±0.27 | 0.27±0.32 | 0.05 (0.1) | – | |
| Euryarchaeota | Methanobrevibacter | 0.01±0.04 | 0.40±0.50 | 0.23±0.31 | 0.001 (0.04) | 0.002 (0.03) |
| Firmicutes | Selenomonas | 0.00±0.00 | 0.24±0.41 | 4.1±8.3 | 0.03 (0.1) | <0.001 (0.003) |
| Peptostreptococcus | 0.00±0.00 | 1.3±2.4 | 2.1±2.6 | <0.001 (0.01) | 0.001 (0.01) | |
| Clostridium | 0.12±0.42 | 0.28±0.30 | 0.45±0.56 | 0.002 (0.04) | 0.001 (0.01) | |
| Dialister | 0.12±0.30 | 1.5±1.5 | 1.4±1.4 | 0.006 (0.05) | 0.003 (0.03) | |
| Parvimonas | 0.01±0.01 | 1.6±2.9 | 2.3±3.3 | 0.02 (0.1) | 0.007 (0.06) | |
| [Mogibacteriaceae] spp | 0.05±0.08 | 0.24±0.29 | 0.22±0.22 | 0.02 (0.1) | 0.009 (0.07) | |
| Bulleidia | 0.01±0.02 | 0.30±0.76 | 0.58±1.1 | – | 0.02 (0.1) | |
| Unclassified Clostridiales | 0.17±0.32 | 0.44±0.44 | 0.31±0.23 | 0.004 (0.05) | 0.03 (0.2) | |
| Streptococcus | 10±9.6 | 3.7±6.0 | 4.0±3.4 | 0.005 (0.05) | – | |
| Oscillospira | 0.32±0.37 | 0.94±0.60 | 0.71±0.57 | 0.007 (0.05) | – | |
| Christensenellaceae spp | 0.05±0.13 | 0.19±0.28 | 0.13±0.25 | 0.02 (0.1) | – | |
| Clostridiaceae spp | 0.48±0.95 | 1.4±1.5 | 1.5±3.2 | 0.02 (0.1) | – | |
| Ruminococcaceae spp | 2.2±2.9 | 6.4±5.3 | 4.8±4.9 | 0.02 (0.1) | – | |
| Clostridiales spp | 1.6±1.6 | 3.6±2.6 | 3.1±2.6 | 0.02 (0.1) | – | |
| Ruminococcus | 0.52±0.91 | 2.0±2.7 | 1.1±1.5 | 0.03 (0.1) | – | |
| Fusobacteria | Fusobacterium | 0.23±0.60 | 1.5±2.2 | 7.6±7.8 | 0.003 (0.04) | <0.001 (0.006) |
| Proteobacteria | Campylobacter | 0.02±0.06 | 0.07±0.14 | 1.2±2.1 | 0.02 (0.1) | 0.007 (0.06) |
| Pseudomonadaceae spp | 0.25±0.37 | 0.07±0.19 | 0.03±0.06 | – | 0.05 (0.2) | |
| Bilophila | 0.08±0.18 | 0.20±0.17 | 0.08±0.08 | 0.007 (0.05) | – | |
| Spirochaetes | Treponema | 0.00±0.00 | 0.02±0.06 | 0.44±1.4 | – | 0.02 (0.1) |
Data are presented as mean±SD.
Wilcoxon rank sum test comparing colon cancer mucosa or tumour to non-cancer control mucosa.
Square brackets indicate the Greengenes database notation for proposed taxonomy.
Only p≤0.05 are shown.
Values in bold indicate FDR≤0.05.
FDR, false discovery rate (Benjamini-Hochberg).