Microbiota alterations with probiotic intervention in patients with colon cancer at surgery
| Genus | Effect of probiotic | Faecal | Mucosa | Tumour | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No Probiotic abundance (%), n=7 | Probiotic abundance (%), n=8 | p Value (FDR) | No probiotic abundance (%), n=6 | Probiotic abundance (%), n=7 | p Value (FDR) | No probiotic abundance (%), n=5 | Probiotic abundance (%), n=7 | p Value (FDR) | ||
| Clostridiales spp | Increase | 3.5±3.1 | 8.5±4.1 | 0.02 (0.3) | 2.8±2.0 | 7.5±3.3 | 0.01 (0.3) | 1.9±1.7 | 6.7±2.8 | 0.01 (0.3) |
| Faecalibacterium | Increase | 3.2±2.6 | 6.5±2.0 | 0.02 (0.3) | 3.3±2.8 | 8.1±3.5 | 0.02 (0.3) | 2.7±2.8 | 6.8±3.1 | 0.03 (0.4) |
| [Eubacterium] | Increase | 0.86±1.8 | 2.9±2.7 | 0.05 (0.3) | 0.50±0.73 | 2.1±1.9 | 0.04 (0.3) | – | – | – |
| Roseburia | Increase | – | – | – | 0.05±0.07 | 1.7±2.2 | 0.04 (0.3) | 0.04±0.03 | 1.9±2.2 | 0.007 (0.3) |
| Lachnospira | Increase | – | – | – | 0.10±0.08 | 1.4±0.85 | 0.03 (0.3) | 0.10±0.07 | 1.3±0.78 | 0.03 (0.4) |
| Fusobacterium | Decrease | 0.81±0.87 | 0.03±0.05 | 0.01 (0.3) | – | – | – | – | – | – |
| Erysipelotrichaceae spp | Increase | 0.42±0.59 | 1.3±1.0 | 0.02 (0.3) | – | – | – | – | – | – |
| Coriobacteriaceae spp | Increase | 0.49±0.46 | 1.3±0.75 | 0.04 (0.3) | – | – | – | – | – | – |
| Porphyromonas | Decrease | 0.43±0.56 | 0.00±0.00 | 0.05 (0.3) | – | – | – | – | – | – |
| [Prevotella] | Decrease | 0.22±0.38 | 0.00±0.00 | 0.05 (0.3) | – | – | – | – | – | – |
| Peptostreptococcus | Decrease | 0.42±0.71 | 0.04±0.06 | 0.05 (0.3) | – | – | – | – | – | – |
| Unclassified Rikenellaceae | Increase | – | – | – | 0.03±0.08 | 1.1±2.1 | 0.03 (0.3) | – | – | – |
| Bacteroidales spp | Decrease | – | – | – | 0.68±1.6 | 0.00±0.00 | 0.04 (0.3) | – | – | – |
| Unclassified Clostridiales | Increase | – | – | – | – | – | – | 0.12±0.14 | 0.72±0.72 | 0.01 (0.3) |
| [Barnesiellaceae] spp | Increase | – | – | – | – | – | – | 0.07±0.11 | 0.24±0.15 | 0.03 (0.3) |
Data are presented as mean±SD.
Wilcoxon rank sum test comparing no probiotic with probiotic for each sample type.
Square brackets indicate the Greengenes database notation for proposed taxonomy.
Only p≤0.05 are shown.
FDR, false discovery rate (Benjamini-Hochberg).