T-RFs corresponding to | HCs (n=21) | FD (n=24) | p Value | ||
---|---|---|---|---|---|
Before LG21 treatment | After LG21 treatment | HC vs FD before | FD before vs FD after | ||
Bifidobacterium | 0.0 (0.0–0.9)* | 2.5 (0.2–5.4) | 0.4 (0.2–0.7) | <0.001 | 0.003 |
Order Lactobacillales | 34.4 (22.3–46.2) | 28.0 (17.7–35.7) | 21.0 (11.7–39.2) | 0.24 | 0.12 |
Prevotella | 37.4 (18.8–52.1) | 28.3 (19.1–26.1) | 39.8 (25.6–52.1) | 0.04† | 0.001‡ |
Clostridium cluster IV | 0.7 (0.0–2.1) | 1.0 (0.4–2.8) | 1.1 (0.6–1.8) | 0.12 | 0.78 |
Clostridium subcluster XIVa | 10.8±5.4 | 12.3±4.6 | 10.2±3.9 | 0.33 | 0.09 |
Clostridium cluster IX | 3.5 (1.9–4.8) | 4.3 (3.3–7.1) | 4.3 (2.4–6.6) | 0.02 | 0.32 |
Clostridium cluster XI | 0.0 (0.0–0.0) | 0.4 (0.0–1.1) | 0.0 (0.0–0.0) | <0.001 | 0.007 |
Clostridium cluster XVIII | 0.0 (0.0–1.2) | 1.1 (0.6–1.5) | 1.8 (0.8–2.5) | 0.004 | 0.26 |
Others | 6.9 (5.3–8.5) | 13.2 (8.9–17.9) | 6.2 (4.2–8.8) | <0.001 | 0.002 |
*Median (IQR).
†OR (FD before vs HC) 1.27, 95% CI 1.01 to 1.59, p=0.04 by a logistic regression analysis in which the volume and the pH and the abundance of Prevotella were included in the independent variables.
‡OR (FD after vs FD before) 1.76, 95% CI 1.28 to 2.42, p<0.001 by the same analysis as that noted above.
FD, functional dyspepsia; HC, healthy control; LG21, Lactobacillus gasseri OLL2716; T-RFLP, terminal restriction fragment length polymorphism.