Table 2

Histopathological changes of the mucosa induced by hyperbaric oxygen therapy in patients with refractory ulcerative colitis

Pathological featureMedian* (range)
Median (range)
p Value†
Architectural changes0.3 (0.2–0.3)0.3 (0.2–0.3)>0.05
Chronic inflammation1.3 (1.2–1.3)1.1 (1–1.1)<0.001
Eosinophils in the lamina propria2.15 (2–2.5)2.05 (2–2.2)<0.001
Neutrophils in the lamina propria2.1 (2.0–2.1)2.0 (2.0–2.0)<0.001
Neutrophils in the epithelium3.3 (3.1–3.3)3.1 (3.1–3.2)<0.001
Crypt destruction4.3 (4.1–4.3)4.1 (4–4.1)<0.001
Surface erosions/ulcerations5.3 (5.2–5.3)5.1 (5.0–5.1)<0.001
  • *The median was used to express the central tendency instead of the mean rank, to facilitate interpretation by the reader.

  • †p Value is estimated from Wilcoxon signed rank test.