Table 1

EXALT trial schedule

Study visits	Baseline										End-of- intervention	Follow-up
	Preliver transplant (LT) (variable time-line)						Transplant	Post-LT (fixed time-line)
	Visit 1	Visit 2	Visit 3	Visit 4	Visit 5	Visit 6	Transplant	Inpatient stay	Visit 7	Visit 8	Visit 9	Visit 10
Time points	0 weeks	6 weeks	12 weeks	24 weeks	36 weeks	48 weeks	52 week cut-off*	Inpatient stay	6 weeks post	12 weeks post	24 weeks post	48 weeks post
Time points	0 weeks	(±7 days)	(±7 days)	(±7 days)	(±14 days	(±14 days)	52 week cut-off*	day 10±3 days	(±7 days)	(±7 days)	(±14 days)	(±14 days)
Consent	X
Randomisation (intervention vs control))	X
Clinical examination and review (routine clinic)	X	X	X	X	X	X	X	X	X	X	X	X
Standard bloods pre-LT (FBC, U+E, LFTs, AST, GGT, INR, CRP, nutrition, ammonia)	X	X	X	X	X	X	X
Standard bloods post-LT (FBC, U+E, LFTs, AST, GGT, INR, CRP, nutrition, tacrolimus)								X	X	X	X	X
Standard clinic observations (BP, dry BMI, weight, hand grip strength, MAMC)	X	X	X	X	X	X	X	X	X	X	X	X
Frailty/functionality assessment (LFI, DASI)	X	X	X	X	X	X	X	X	X	X	X	X
Primary outcome SF-36v2 questionnaire	X	X	X	X	X	X		X	X	X	X	X
Behavioural/psychological questionnaires (HCCQ, PNES, BREQ-2)	X	X	X	X	X	X		X	X	X	X	X
Serious adverse events (complications/morbidity)	X	X	X	X	X	X	X	X	X	X	X	X
LT data (date, donor details, organ support, ICU stay)							X
Exercise adherence: review participant ‘exercise’ diary		X	X	X	X	X	X		X	X	X	X
Exercise Adherence: Acceleromter	Weeks 0–2	4–6	10–12	22–24					Weeks 4–6	10–12	22–24
Mechanistic 'muscle' substudy (n=100, optional):
CPET, muscle USS, 6MWT, specialist biomarkers	X	X				(X)					X
Interventions:
Intervention: home-based exercise and theory-based motivation support programme	X	X	X	X	X	X		X	X	X	X
Intervention: Telecall (15–30 min)		Week 2,4	8, 10	16,20					4	8	16
Control: standard of care patient ‘exercise’ advice leaflet	X							X

*52 (+2) week cut-off: study intervention will stop if participant has not had their LT by 52 weeks. (X) optional substudy consent if have not undergone LT within the 1-year time frame.
AST, aspartate transferase; BMI, body mass index; BP, blood pressure; BREQ-2, Behavioural Regulation in Exercise Questionaire-2; CPET, cardiopulmonary exercise test; CRP, C reactive protein; DASI, Duke Activity Status Index; EXALT, EXercise and motivAtional programme before and after Liver Transplantation; FBC, full blood count; GGT, gamma-glutamyl transferase; HCCQ, Healthcare Climate Questionnaire; ICU, intensive care unit; INR, international normalised ratio; LFI, Liver frailty index; LFTs, liver function tests; MAMC, mid-arm muscle circumference; 6MWT, 6 min walk test; PNES, Psychological Need Satisfaction in Exercise Scale; U+E, urea and electrolyte; USS, Ultrasound.