Cumulative dose of corticosteroids* | Period | Absolute risk (95% CI) | Rate per 1000 PYRs (95% CI) | Crude HR (95% CI) | Adjusted HR† (95% CI) |
---|---|---|---|---|---|
Non-use | 7 days | 4.4 (3.8 to 5.1) | 6.46 (5.47 to 7.44) | ||
30 days | 8.8 (7.9 to 9.7) | 3.12 (2.78 to 3.45) | |||
90 days | 11.9 (10.9 to 12.9) | 1.46 (1.33 to 1.60) | |||
1 year | 15.6 (14.4 to 16.8) | 0.51 (0.47 to 0.55) | |||
≤625 mg | 7 days | 15.3 (10.1 to 23.0) | 23.54 (12.96 to 34.13) | 3.65 (2.27 to 5.87) | 2.38 (1.44 to 3.92) |
30 days | 26.6 (19.7 to 35.3) | 10.95 (7.22 to 14.69) | 3.38 (2.37 to 4.84) | 1.92 (1.32 to 2.79) | |
90 days | 37.9 (30.0 to 47.1) | 5.93 (4.24 to 7.63) | 3.73 (2.76 to 5.04) | 2.10 (1.53 to 2.87) | |
1 year | 40.5 (32.4 to 49.7) | 1.80 (1.30 to 2.30) | 3.18 (2.38 to 4.24) | 1.81 (1.34 to 2.45) | |
>625 to 2000 mg | 7 days | 13.2 (8.6 to 19.9) | 20.36 (11.21 to 29.52) | 3.15 (1.96 to 5.06) | 1,76 (1.06 to 2.94) |
30 days | 31.2 (24.4 to 39.5) | 13.15 (9.31 to 16.99) | 4.03 (2.95 to 5.50) | 2.08 (1.48 to 2.93) | |
90 days | 39.6 (32.1 to 48.1) | 6.41 (4.75 to 8.07) | 3.97 (3.01 to 5.23) | 2.03 (1.51 to 2.74) | |
1 year | 53.4 (45.4 to 61.8) | 2.68 (2.08 to 3.28) | 4.36 (3.43 to 5.54) | 2.24 (1.72 to 2.91) | |
>2000 to 3500 mg | 7 days | 16.4 (11.2 to 23.7) | 25.67 (15.18 to 36.16) | 3.98 (2.57 to 6.16) | 2.74 (1.62 to 4.64) |
30 days | 30.0 (23.2 to 38.4) | 12.46 (8.69 to 16.23) | 3.87 (2.81 to 5.33) | 2.24 (1.52 to 3.30) | |
90 days | 38.2 (30.6 to 46.8) | 6.12 (4.47 to 7.76) | 3.80 (2.85 to 5.05) | 2.17 (1.54 to 3.06) | |
1 year | 48.9 (40.9 to 57.6) | 2.37 (1.80 to 2.94) | 3.92 (3.05 to 5.06) | 2.18 (1.61 to 2.97) | |
>3500 mg | 7 days | 10.5 (5.6 to 19.1) | 15.71 (5.45 to 25.97) | 2.44 (1.24 to 4.76) | 1.55 (0.75 to 3.24) |
30 days | 20.9 (13.8 to 31.2) | 8.30 (4.47 to 12.14) | 2.59 (1.61 to 4.16) | 1.31 (0.78 to 2.19) | |
90 days | 26.8 (18.7 to 37.6) | 3.80 (2.25 to 5.35) | 2.50 (1.64 to 3.80) | 1.21 (0.77 to 1.90) | |
1 year | 46.2 (36.1 to 57.7) | 1.91 (1.30 to 2.52) | 3.33 (2.40 to 4.63) | 1.59 (1.11 to 2.29) |
*Cumulative dose defined as the 1-year cumulative dose of systemic corticosteroids among current users, calculated as prednisone dose equivalents.
†HR adjusted for age, sex, use of cardiovascular medication, hypertension, COPD, liver disease or chronic pancreatitis, alcoholism-related diseases other than those affecting the liver or pancreas, inflammatory bowel disease, rheumatoid arthritis, connective tissue disease, malignancies and modified Charlson Comorbidity Index score.
COPD, chronic obstructive pulmonary disease; PYR, person year.