Patient demographics and clinical characteristics by severity group*
| Demographic/clinical characteristic | Group 1 most severe (N=13 444) | Group 2 moderate severity (N=23 299) | Group 3 least severe (N=23 836) |
| Demographics | |||
| Age, years, mean (SD) | 63 (12) | 64 (12) | 64 (12) |
| Females, n (%) | 4840 (36) | 9552 (41) | 10 249 (43) |
| Race, n (%) | |||
| White | 9545 (71) | 16 309 (70) | 17 162 (72) |
| Black or African American | 941 (7) | 2563 (11) | 2622 (11) |
| Asian | 269 (2) | 466 (2) | 477 (2) |
| American Native or Alaska Native | 134 (1) | 0 | 0 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 |
| Unknown | 2554 (19) | 3961 (17) | 3575 (15) |
| Ethnicity, n (%) | |||
| Not Hispanic or Latino | 8604 (64) | 15 377 (66) | 16 447 (69) |
| Hispanic or Latino | 2151 (16) | 2796 (12) | 3099 (13) |
| Unknown | 2689 (20) | 5126 (22) | 4290 (18) |
| Clinical characteristics | |||
| Portal hypertension, n (%) | 9835 (73) | 13 500 (58) | 23 836 (100) |
| Aetiology, n (%) | |||
| Other | 6044 (45) | 10 174 (44) | 9976 (42) |
| Alcohol-associated liver disease | 6646 (49) | 8578 (37) | 7675 (32) |
| Chronic viral hepatitis | 3852 (29) | 7180 (31) | 6464 (27) |
| Metabolic-associated steatohepatitis | 2018 (15) | 3450 (15) | 2931 (12) |
| Autoimmune hepatitis | 413 (3) | 770 (3) | 729 (3) |
| Haemochromatosis | 163 (1) | 360 (2) | 374 (2) |
| Primary sclerosing cholangitis | 165 (1) | 210 (1) | 259 (1) |
| Wilson’s disease | 43 (0.003) | 41 (0.002) | 56 (0.002) |
| Comorbidities, n (%) | |||
| Type 2 diabetes | 5292 (39) | 8984 (39) | 9392 (39) |
| Neoplasms (all) | 4689 (35) | 8331 (36) | 8398 (35) |
| Benign neoplasms | 3384 (25) | 6243 (27) | 2744 (12) |
| Malignant neoplasms | 2170 (16) | 2659 (11) | 3582 (15) |
| Alcohol abuse | 5207 (39) | 6965 (30) | 7410 (31) |
| Major depression | 3023 (22) | 5746 (25) | 6668 (28) |
| Ischaemic heart diseases | 2411 (18) | 3703 (16) | 4696 (20) |
| Heart failure (all) | 1587 (12) | 3372 (14) | 5198 (22) |
| Heart failure with preserved ejection fraction | 1182 (9) | 2095 (9) | 3070 (13) |
| Stroke | 921 (7) | 1983 (9) | 2585 (11) |
| Heart failure with reduced ejection fraction | 351 (3) | 907 (4) | 1866 (8) |
| HIV | 276 (2) | 621 (3) | 1115 (5) |
| Sarcopenia | 50 (0.004) | 32 (0.001) | 50 (0.002) |
| Antiviral use, n (%) | |||
| Never or >5 years ago | 10 732 (80) | 18 962 (81) | 19 190 (81) |
| 1–5 years ago | 1160 (9) | 2547 (11) | 2325 (10) |
| In the last year | 1313 (10) | 2731 (12) | 2734 (11) |
*The run date for this analysis was 17 May 2022.