Demographic and clinical data
| HCs (n=44) | FD (n=44) | p Value | |||
|---|---|---|---|---|---|
| Before LG21 treatment | After LG21treatment | HC vs FD before | FD before vs FD after | ||
| Age of years | 41.5 (30.3–48.5)* | 42.5 (34.5–50.3) | 0.27 | ||
| Male/female | 30/14 | 22/22 | 0.083 | ||
| FSSG scores | |||||
| Epigastric pain-like | 1.0 (0–2.0) | 12.0 (7.8–15) | 4.0 (3.0–6.3) | <0.001 | <0.001 |
| Postprandial distress-like | 2.0 (1.0–3.0) | 15.0 (13.0–17.3) | 7.3 (3.0–10.3) | <0.001 | <0.001 |
| GF | |||||
| Volume (mL) | 18.6±9.2† | 23.4±10.4 | 19.7±9.5 | 0.026 | 0.046 |
| pH | 1.65 (1.40–1.86) | 1.58 (1.43–1.85) | 1.84 (1.56–3.81) | 0.72 | 0.012 |
| Number of cultured bacteria (log10 CFU/mL) | 2.3 (1.3–4.8) | 2.4 (1.3–4.0) | 3.7 (1.7–6.8) | 0.91 | 0.050 |
| Serum | |||||
| Pepsinogen I | 37.7 (29.4–44.0) | 33.3 (27.5–41.9) | 34.7 (29.9–44.8) | 0.36 | 0.045 |
| PG I/II ratio | 5.3 (4.8–6.0) | 5.1 (4.6–5.8) | 5.3 (4.7–6.3) | 0.22 | 0.052 |
| % urinary sucrose excretion (×103) | 6.2 (3.8–10) | 9.5 (4.8–16) | 10 (5.3–14) | 0.16 | 0.82 |
*Median (IQR).
†Mean±SD.
CFU, colony-forming unit; FD, functional dyspepsia; FSSG, frequency scale for the symptoms of GERD; GF, gastric fluid; HC, healthy control; LG21, Lactobacillus gasseri OLL2716; PGI/II, pepsinogens I/II.