Table 1

Demographic, clinical and county-level socioeconomic factors associated with 5-year cancer-specific survival in appendiceal and cecal adenocarcinoma using multivariable Cox regression analysis

Variable	Category	HR	95% CI	P value
Sex	Male	1
Sex	Female	0.90	0.88 to 0.92	<0.001
Age quartile	Quartile 1: ≤61	1
	Quartile 2: >61 and ≤72	1.16	1.13 to 1.20	<0.001
	Quartile 3: >72 and ≤81	1.29	1.25 to 1.33	<0.001
	Quartile 4: >81	1.68	1.63 to 1.74	<0.001
Year of diagnosis	2005–2016	1
	1991–2005	1.30	1.26 to 1.33	<0.001
	1975–1990	1.57	1.50 to 1.64	<0.001
Race	White	1
	Asian/Pacific Islander/American Indian/Alaska Native	0.94	0.89 to 0.98	0.007
	Black	1.15	1.11 to 1.19	<0.001
Ethnicity	Non-Hispanic	1
Ethnicity	Hispanic	0.95	0.91 to 0.99	0.008
Marital status	Married	1
	Divorced	1.16	1.12 to 1.21	<0.001
	Separated	1.06	0.98 to 1.16	0.17
	Never married	1.15	1.11 to 1.19	<0.001
	Widowed	1.09	1.06 to 1.12	<0.001
	Unmarried or domestic partner	0.76	0.44 to 1.31	0.33
	Unknown	1.03	0.98 to 1.09	0.22
Tumour location	Cecum	1
Tumour location	Appendix	0.71	0.68 to 0.74	<0.001
Histology	Non-mucinous	1
	Mucinous	0.93	0.90 to 0.96	<0.001
	Signet-ring cell	1.25	1.18 to 1.33	<0.001
Stage	Local	1
	Regional	3.55	3.39 to 3.72	<0.001
	Distant	14.06	13.39 to 14.76	<0.001
	Unknown	4.53	4.31 to 4.76	<0.001
Grade	I: Well differentiated	1
	II: Moderately differentiated	1.35	1.29 to 1.41	<0.001
	III: Poorly differentiated	2.05	1.96 to 2.15	<0.001
	IV: Undifferentiated; anaplastic	2.31	2.15 to 2.50	<0.001
	Unknown	1.46	1.39 to 1.53	<0.001
Surgery	Surgery	1
	No surgery	2.88	2.79 to 2.97	<0.001
	Unknown	2.99	2.67 to 3.36	<0.001
Chemotherapy	Chemotherapy	1
Chemotherapy	No chemotherapy/unknown	1.00	0.97 to 1.02	0.82
Per cent smokers	>50th percentile	1.01	0.98 to 1.04	0.38
Per cent smokers	<50th percentile	1
Per cent college education	>50th percentile	0.99	0.97 to 1.02	0.59
Per cent college education	<50th percentile	1
Per cent minority	>50th percentile	1.04	0.96 to 1.07	0.05
Per cent minority	<50th percentile	1
Per cent urban population	>50th percentile	0.99	0.96 to 1.01	0.25
Per cent urban population	<50th percentile	1
Per cent foreign-born population	>50th percentile	0.97	0.94 to 1.03	0.06
Per cent foreign-born population	<50th percentile	1
Per cent below poverty line	>50th percentile	1.06	1.03 to 1.09	0.0002
Per cent below poverty line	<50^tthpercentile	1
Per cent colorectal cancer screening	>50th percentile	0.94	0.92 to 0.96	<0.001
Per cent colorectal cancer screening	<50th percentile	1

Significant p values are shown in bold.
*The significance level was set at p<0.05.