Characteristics and delay intervals for a cohort of colorectal cancer patients <50 years
| Characteristic | Overall N=6853 | 15–39 years N=1540 | 40–44 years N=1827 | 45–49 years N=3486 | P-value |
| Age (years) | 45.0 (40.0, 47.0) | 35.0 (31.0, 38.0) | 42.0 (41.0, 43.0) | 47.0 (46.0, 49.0) | <0.001 |
| Sex | 0.4 | ||||
| Male | 3587 (52%) | 809 (53%) | 931 (51%) | 1847 (53%) | |
| Female | 3266 (48%) | 731 (47%) | 896 (49%) | 1639 (47%) | |
| ON-Marg Summary Score | 3.00 (2.25, 3.50) | 3.00 (2.50, 3.75) | 2.75 (2.25, 3.50) | 3.00 (2.25, 3.50) | 0.017 |
| Missing | 76 | 13 | 15 | 48 | |
| Income quintile | 0.009 | ||||
| 1 | 1174 (17%) | 272 (18%) | 310 (17%) | 592 (17%) | |
| 2 | 1154 (17%) | 290–300* (19%) | 290–300* (16%) | 568 (16%) | |
| 3 | 1234 (18%) | 289 (19%) | 352 (19%) | 593 (17%) | |
| 4 | 1298 (19%) | 289 (19%) | 353 (19%) | 656 (19%) | |
| 5 | 1231 (18%) | 252 (16%) | 332 (18%) | 647 (19%) | |
| Rural | 748 (11%) | 139 (9.0%) | 190 (10%) | 419 (12%) | |
| Missing | 14 | <10* | <10* | 11 | |
| Stage (percentages reflect diagnoses 2007 and later) | <0.001 | ||||
| I | 884 (17%) | 161 (13%) | 253 (18%) | 470 (18%) | |
| II | 1082 (21%) | 243 (20%) | 309 (22%) | 530 (20%) | |
| III | 1939 (37%) | 465 (39%) | 491 (35%) | 983 (37%) | |
| IV | 1321 (25%) | 337 (28%) | 338 (24%) | 646 (25%) | |
| Pre-2007 | 1320 | 264 | 360 | 696 | |
| Missing | 307 | 70 | 76 | 161 | |
| Disease site | <0.001 | ||||
| Proximal colon | 2363 (34%) | 603 (39%) | 590 (32%) | 1170 (34%) | |
| Rectum | 2103 (31%) | 461 (30%) | 564 (31%) | 1078 (31%) | |
| Sigmoid and rectosigmoid | 2387 (35%) | 476 (31%) | 673 (37%) | 1238 (36%) | |
| Use of lower GI endoscopy in patient LHIN (procedures per 100 000 residents in last year) | 4181 (3411, 4648) | 4208 (3482, 4681) | 4179 (3401, 4639) | 4166 (3369, 4632) | 0.029 |
| Time from presentation to first abdominal/pelvic CT or MRI (days) | 0.6 | ||||
| Median (IQR) | 46 (7, 142) | 47 (7, 165) | 47 (7, 140) | 46 (7, 130) | |
| Mean (SD) | 92 (108) | 98 (114) | 92 (109) | 88 (105) | |
| Range | 0, 500 | 0, 486 | 0, 500 | 0, 482 | |
| Missing | 4221 | 866 | 1129 | 2226 | |
| Time from presentation to first lower endoscopy (days) | 0.071 | ||||
| Median (IQR) | 70 (28, 163) | 79 (27, 182) | 70 (30, 172) | 67 (28, 154) | |
| Mean (SD) | 111 (108) | 117 (112) | 113 (109) | 107 (106) | |
| Range | 0, 493 | 0, 486 | 0, 456 | 0, 493 | |
| Missing | 1680 | 451 | 416 | 813 | |
| Doctor interval (presentation to first investigation; days) | 0.9 | ||||
| Median (IQR) | 5 (0, 36) | 4 (0, 42) | 4 (0, 36) | 5 (0, 35) | |
| Mean (SD) | 36 (68) | 38 (70) | 36 (68) | 34 (66) | |
| Range | 0, 462 | 0, 456 | 0, 409 | 0, 462 | |
| Missing | 99 | 31 | 18 | 50 | |
| System interval (first investigation to treatment; days) | 0.2 | ||||
| Median (IQR) | 77 (36, 160) | 78 (34, 168) | 80 (39, 163) | 74 (37, 155) | |
| Mean (SD) | 114 (107) | 116 (109) | 117 (108) | 112 (105) | |
| Range | 0, 763 | 0, 601 | 0, 638 | 0, 763 | |
| Missing | 470 | 108 | 108 | 254 | |
| Diagnostic interval (presentation to diagnosis; days) | 0.002 | ||||
| Median (IQR) | 78 (28, 186) | 89 (28, 208) | 83 (30, 195) | 72 (27, 176) | |
| Mean (SD) | 121 (117) | 129 (121) | 124 (117) | 115 (115) | |
| Range | 0, 519 | 0, 503 | 0, 519 | 0, 502 | |
| Treatment interval (diagnosis to treatment; days) | <0.001 | ||||
| Median (IQR) | 23 (7, 40) | 20 (4, 35) | 24 (8, 41) | 25 (8, 42) | |
| Mean (SD) | 29 (31) | 25 (31) | 29 (30) | 30 (32) | |
| Range | 0, 357 | 0, 343 | 0, 357 | 0, 350 | |
| Missing | 384 | 82 | 91 | 211 | |
| Overall interval (presentation to treatment; days) | 0.052 | ||||
| Median (IQR) | 109 (55, 218) | 113 (51, 233) | 114 (58, 226) | 106 (56, 208) | |
| Mean (SD) | 148 (121) | 152 (125) | 153 (121) | 145 (120) | |
| Range | 0, 763 | 0, 631 | 0, 638 | 0, 763 | |
| Missing | 384 | 82 | 91 | 211 | |
Presented are median (IQR) or N (%) unless otherwise specified.
*Ranges are given so as to suppress small cells of missing data
GI, gastrointestinal; LHIN, local health integration network.