Table 1

Participant inclusion and exclusion criteria.

Eligibility criteriaExclusion criteria
Age≥18 yearsAge<18 years
Confirmed moderate to severe IBD based on endoscopic evaluation (Mayo endoscopic sub-score>2, Simple Endoscopic Score for Crohn’s disease (SES-CD)>7), clinical scoring tools (Crohn’s Disease Activity Index (CDAI)>220, Harvey-Bradshaw Index (HBI)>8, partial Mayo score>5) and faecal calprotectin (>250 ug/g).Inactive or mild IBD.
Must be able to provide written informed consent and complete questionnaires.Inability to participate in the exercise programme (unable to perform 6-minute walk test (6-MWT), unable to attend for assessment of parameters at any time point).
Must be physically able to complete an exercise programme.An uncontrolled cardiovascular condition such as unstable angina, uncontrolled cardiac arrhythmias, uncontrolled symptomatic heart failure or symptomatic severe aortic stenosis.
A significant musculoskeletal condition, neurological condition, mental illness or intellectual disability that restricts participation in a physical exercise programme.
Previous biologic or small molecule therapy use.Pregnant women.
Healthy controls will be excluded if they have a history of underlying inflammatory conditions.
  • IBD, inflammatory bowel disease.