Liver enzyme levels at different follow up periods
| Overall (n=85) | Paracetamol (n=67) | Non-paracetamol (n=18) | P value | |
| Follow-up time | 16.0 (10.0–31.0) | 15.0 (9.0–30.5) | 19.0 (12.0–30.8) | 0.491 |
| Day 7 | ||||
| Alanine aminotransferase | 701.6 (455.5–1013.0) | 701.6 (455.5–1009.9) | 680.4 (476.5–1230.8) | 0.799 |
| Aspartate aminotransferase | 85.3 (68.8–116.6) | 83.8 (68.5–115.2) | 97.2 (75.2–214.0) | 0.212 |
| Alkaline phosphatase | 134.8 (108.2–181.3) | 133.0 (103.7–182.2) | 151.3 (118.8–175.0) | 0.566 |
| Gamma-glutamyl transferase | 210.3 (135.9–340.9) | 218.8 (135.9–320.9) | 204.9 (161.8–449.4) | 0.524 |
| Bilirubin | 119.2 (43.9–231.8) | 134.7 (56.5–238.0) | 75.8 (38.3–201.5) | 0.448 |
| Day 15 | ||||
| Alanine aminotransferase | 89.8 (61.1–121.4) | 88.7 (70.3–116.3) | 104.3 (52.2–130.2) | 0.986 |
| Aspartate aminotransferase | 56.5 (37.4–77.8) | 56.5 (37.9–73.2) | 59.7 (35.4–85.7) | 0.909 |
| Alkaline phosphatase | 118.0 (105.0–160.4) | 116.7 (105.0–171.7) | 120.0 (108.8–145.7) | 0.901 |
| Gamma-glutamyl transferase | 129.3 (74.5–303.4) | 126.7 (75.0–269.0) | 253.7 (75.2–469.5) | 0.682 |
| Bilirubin | 213.6 (27.9–300.8) | 242.7 (60.0–291.3) | 24.0 (18.5–212.3) | 0.130 |
| Day 30 | ||||
| Alanine aminotransferase | 40.4 (30.0–59.5) | 51.7 (35.2–99.0) | 32.0 (20.0–32.0) | 0.061 |
| Aspartate aminotransferase | 86.0 (68.1–113.2) | 86.0 (68.1–113.2) | --- | --- |
| Alkaline phosphatase | 123.8 (78.2–150.8) | 138.0 (110.7–175.8) | 67.0 (64.0–117.0) | 0.079 |
| Gamma-glutamyl transferase | 115.3 (65.2–173.2) | 146.5 (84.8–278.8) | 72.0 (39.0–80.0) | 0.157 |
| Bilirubin | 130.0 (14.2–364.1) | 203.5 (74.0–373.8) | 9.0 (8.0–14.0) | 0.047 |
| Day 60 | ||||
| Alanine aminotransferase | 61.0 (39.5–100.0) | 72.0 (52.8–108.5) | 23.0 (23.0–23.0) | 0.134 |
| Aspartate aminotransferase | 95.0 (52.0–144.8) | 95.0 (52.0–144.8) | --- | --- |
| Alkaline phosphatase | 177.0 (86.5–202.0) | 179.0 (128.2–212.5) | 61.0 (61.0–61.0) | 0.207 |
| Gamma-glutamyl transferase | 196.0 (96.0–514.5) | 341.0 (157.0–528.8) | 44.0 (44.0–44.0) | 0.134 |
| Bilirubin | 42.0 (19.5–123.0) | 50.0 (27.0–155.5) | 8.0 (8.0–8.0) | 0.134 |
| Day 90 | ||||
| Alanine aminotransferase | 18.0 (12.0–19.9) | 18.0 (16.0–18.6) | 20.8 (14.9–26.6) | 0.999 |
| Aspartate aminotransferase | --- | --- | --- | --- |
| Alkaline phosphatase | 81.2 (69.5–103.9) | 81.2 (64.6–105.6) | 88.5 (78.8–98.2) | 0.999 |
| Gamma-glutamyl transferase | 35.5 (25.2–57.2) | 51.2 (37.2–146.9) | 19.5 (17.8–21.2) | 0.064 |
| Bilirubin | 9.3 (5.6–17.0) | 15.6 (11.0–21.4) | 4.8 (4.4–5.1) | 0.064 |
| Day 180 | ||||
| Alanine aminotransferase | 20.0 (13.5–40.8) | 30.5 (14.5–48.0) | 17.5 (13.8–21.2) | 0.355 |
| Aspartate aminotransferase | 52.0 (52.0–52.0) | 52.0 (52.0–52.0) | --- | --- |
| Alkaline phosphatase | 140.5 (103.5–166.2) | 160.5 (144.8–184.8) | 86.0 (82.0–90.0) | 0.064 |
| Gamma-glutamyl transferase | 133.5 (22.5–360.8) | 320.5 (186.8–418.8) | 18.5 (17.2–19.8) | 0.064 |
| Bilirubin | 7.0 (3.2–11.5) | 6.5 (3.0–11.5) | 8.0 (6.0–10.0) | 0.639 |
Data are median (IQR).
Definitions: day 7 (between day 6 and 8); day 15 (between day 14 and 16); day 30 (between day 29 and 31); day 60 (between day 55 and 65); day 90 (between day 80 and 100); day 180 (between day 160 and 200).