Baseline characteristics, IBD phenotype and biomarkers at ASUC diagnosis
| Variable | N | Inpatients n=695 | Ambulatory n=69 | P value | ||
| Ambulatory from diagnosis n=15 | Initially inpatient and then discharged to ambulatory n=54 | |||||
| Sex | F | 764 | 50.1% (348/695) | 53.3% (8/15) | 38.9% (21/54) | 0.27 |
| M | 764 | 49.9% (347/695) | 46.7% (7/15) | 61.1% (33/54) | ||
| Age (years) | 764 | 37.0 (26.0–53.0) | 30.0 (22.0–39.0) | 44.5 (33.0–58.8) | 0.02 | |
| IBD type | ||||||
| UC | 764 | 95.7% (665/695) | 93.3% (14/15) | 92.6% (50/54) | 0.34 | |
| IBD-U | 764 | 4.3% (30/695) | 6.7% (1/15) | 7.4% (4/54) | ||
| BMI | 424 | 24.4 (21.2–27.9) | 24.0 (20.4–28.9) | 24.9 (22.8–30.9) | 0.31 | |
| No of comorbidities | ||||||
| 0 | 764 | 72.2% (502/695) | 60.0% (9/15) | 64.8% (35/54) | 0.45 | |
| 1 | 764 | 19.3% (134/695) | 26.7% (4/15) | 22.2% (12/54) | ||
| 2 | 764 | 5.5% (38/695) | 6.7% (1/15) | 7.4% (4/54) | ||
| >2 | 764 | 3.0% (21/695) | 6.7% (1/15) | 5.6% (3/54) | ||
| Years since diagnosis | 722 | 1.0 (0.0–5.0) | 1.0 (0.0–7.5) | 1.5 (0.0–8.2) | 0.85 | |
| UC extent | ||||||
| E1—proctitis | 693 | 8.5% (54/636) | 8.3% (1/12) | 4.4% (2/45) | 0.53 | |
| E2—left-sided disease | 693 | 47.3% (301/636) | 41.7% (5/12) | 60.0% (27/45) | ||
| E3—pan-colitis | 693 | 44.2% (281/636) | 50.0% (6/12) | 35.6% (16/45) | ||
| Biomarkers at day 1 | ||||||
| Stool frequency | 612 | 10.0 (8.0–15.0) | 12.0 (10.0–14.8) | 10.0 (7.0–13.5) | 0.42 | |
| CRP | 704 | 54.0 (20.0–114.8) | 40.0 (14.0–72.2) | 52.5 (20.0–114.5) | 0.32 | |
| Albumin | 664 | 35.0 (30.0–40.0) | 38.0 (35.0–41.2) | 37.0 (30.5–39.5) | 0.39 | |
| Haemoglobin | 704 | 123.0 (107.0–135.5) | 134.0 (113.5–144.5) | 129.0 (110.0–141.0) | 0.15 | |
| Most recent faecal calprotectin prior to flare (ug/g) | 229 | 501.5 (155.8–1364.0) | 390.0 (78.0–416.0) | 600.0 (244.8–1234.2) | 0.62 | |
P value=Fisher’s exact test or Kruskal-Wallis test for discrete and continuous variables continuous, respectively. Discrete variables displayed % (n/N) and continuous variables median (IQR).
ASUC, acute severe colitis; BMI, body mass index; CRP, C reactive protein; IBD, inflammatory bowel disease; UC, ulcerative colitis.