Variable | N | Inpatient n=695 | Ambulatory, n=69 | P value | |
Ambulatory from diagnosis, n=15 | Initially inpatient and then discharged to ambulatory, n=54 | ||||
Primary outcome | |||||
Colectomy during index ASUC management period | 764 | 15.0% (104/695) | 13.3% (2/15) | 13.0% (7/54) | 0.95 |
Secondary outcomes | |||||
Admitted to hospital during treatment | 764 | 99.9% (694/695) | 40.0% (6/15) | 100.0% (54/54) | 0.0005 |
Corticosteroid therapy | |||||
Received intravenous corticosteroids | |||||
Yes | 758 | 97.4% (672/690) | 100.0% (15/15) | 100.0% (53/53) | 0.74 |
No (straight to biologic) | 2.6% (18/690) | 0.0% (0/15) | 0.0% (0/53) | ||
Type of intravenous corticosteroid | |||||
Hydrocortisone (intravenous) | 740 | 87.6% (589/672) | 20.0% (3/15) | 79.2% (42/53) | 0.0005 |
Methylprednisolone (intravenous) | 740 | 12.4% (83/672) | 80.0% (12/15) | 20.8% (11/53) | |
Responded to corticosteroids | 753 | 71.6% (490/684) | 66.7% (10/15) | 75.9% (41/54) | 0.74 |
Rescue/primary induction therapy | |||||
Received rescue/primary induction therapy | 751 | 40.9% (281/687) | 60.0% (9/15) | 36.7% (18/49) | 0.28 |
Time to rescue/primary induction therapy (days) | 286 | 6.0 (4.0–8.0) | 3.5 (2.0–5.2) | 5.0 (4.5–6.0) | 0.19 |
Responded to rescue/primary induction treatment | 301 | 80.4% (221/275) | 62.5% (5/8) | 88.9% (16/18) | 0.26 |
Surgery | |||||
Time to colectomy (days) | 112 | 12.0 (7.0–21.0) | 16.0 (14.0–43.5) | 6.0 (3.5–13.0) | 0.15 |
Mortality | 754 | 1.2% (8/686) | 0.0% (0/15) | 0.0% (0/53) | 1 |
Duration of hospital treatment (days)* | 695 | 7.0 (5.0–13.0) | 6.0 (6.0–18.0) | 7.0 (5.0–9.0) | 0.47 |
P value=Fisher’s exact test or Kruskal-Wallis test for discrete and continuous variables continuous, respectively. Discrete variables displayed % (n/N) and continuous variables median (IQR).
*Only patients with ambulatory care from diagnosis who were admitted to hospital (n=6) had inpatient stay data captured.
.ASUC, acute severe ulcerative colitis.