Table 3

Primary and secondary outcomes

VariableNInpatient
n=695
Ambulatory, n=69P value
Ambulatory from diagnosis, n=15Initially inpatient and then discharged to ambulatory, n=54
Primary outcome
Colectomy during index ASUC management period76415.0% (104/695)13.3% (2/15)13.0% (7/54)0.95
Secondary outcomes
Admitted to hospital during treatment76499.9% (694/695)40.0% (6/15)100.0% (54/54)0.0005
Corticosteroid therapy
Received intravenous corticosteroids
 Yes75897.4% (672/690)100.0% (15/15)100.0% (53/53)0.74
 No (straight to biologic)2.6% (18/690)0.0% (0/15)0.0% (0/53)
Type of intravenous corticosteroid
 Hydrocortisone (intravenous)74087.6% (589/672)20.0% (3/15)79.2% (42/53)0.0005
 Methylprednisolone (intravenous)74012.4% (83/672)80.0% (12/15)20.8% (11/53)
Responded to corticosteroids75371.6% (490/684)66.7% (10/15)75.9% (41/54)0.74
Rescue/primary induction therapy
Received rescue/primary induction therapy75140.9% (281/687)60.0% (9/15)36.7% (18/49)0.28
Time to rescue/primary induction therapy (days)2866.0 (4.0–8.0)3.5 (2.0–5.2)5.0 (4.5–6.0)0.19
Responded to rescue/primary induction treatment30180.4% (221/275)62.5% (5/8)88.9% (16/18)0.26
Surgery
Time to colectomy (days)11212.0 (7.0–21.0)16.0 (14.0–43.5)6.0 (3.5–13.0)0.15
Mortality 7541.2% (8/686)0.0% (0/15)0.0% (0/53)1
Duration of hospital treatment (days)*6957.0 (5.0–13.0)6.0 (6.0–18.0)7.0 (5.0–9.0)0.47
  • P value=Fisher’s exact test or Kruskal-Wallis test for discrete and continuous variables continuous, respectively. Discrete variables displayed % (n/N) and continuous variables median (IQR).

  • *Only patients with ambulatory care from diagnosis who were admitted to hospital (n=6) had inpatient stay data captured.

  • .ASUC, acute severe ulcerative colitis.