Gender | |
Female | 21 (67.7) |
Male | 10 (32.3) |
Race | |
Caucasian | 19 (61.3) |
African–American | 8 (25.8) |
Other | 4 (12.9) |
Smoking status | |
Never | 20 (64.5) |
Former | 8 (25.8) |
Current | 3 (9.7) |
BMI (mean) (SD) | 25.5±5.7 |
Age at ustekinumab induction in years (median) (IQR) | 36 (27–43) |
Duration of the disease at time of induction in years (median) (IQR) | 12.5 (5.3–18.5) |
Montreal classification—disease location | |
L1—ileal | 2 (6.5) |
L2—colonic | 15 (48.4) |
L3—ileocolonic | 11 (35.5) |
L4—upper disease | 1 (3.2) |
J pouch | 2 (6.5) |
Montreal classification—behaviour of the disease, n (%) | |
B1—non-stricturing, non-penetrating | 15 (48.4) |
B2—stricturing | 3 (9.7) |
B3—penetrating | 13 (41.9) |
Previous history of perianal surgery | 19 (61.3) |
Seton placement | 9 (29) |
Fistulotomy | 4 (12.9) |
Abscess drainage | 2 (6.5) |
Fistulectomy | 2 (6.5) |
Advancement flap | 1 (3.2) |
Unknown | 1 (3.2) |
Intestinal resection prior to induction | 13 (41.9) |
Current seton at time of ustekinumab induction | 8 (25.8) |
Concurrent immunomodulators at induction | 10 (32.6) |
Previous use of immunomodulators | |
Azathioprine | 17 (54.8) |
Methotrexate | 7 (22.6) |
6-mercaptopurine | 6 (19.4) |
Prior biological exposure | |
Infliximab | 25 (80.6) |
Adalimumab | 25 (80.6) |
Vedolizumab | 10 (32.3) |
Certolizumab pegol | 6 (19.4) |
Golimumab | 1 (3.2) |