Table 1

Patient demographics and clinical characteristics

Demographic variableFrequency (%)
Gender
Female21 (67.7)
Male10 (32.3)
Race
Caucasian19 (61.3)
African–American8 (25.8)
Other4 (12.9)
Smoking status
Never20 (64.5)
Former8 (25.8)
Current3 (9.7)
BMI (mean) (SD)25.5±5.7
Age at ustekinumab induction in years (median) (IQR)36 (27–43)
Duration of the disease at time of induction in years (median) (IQR)12.5 (5.3–18.5)
Montreal classification—disease location
L1—ileal2 (6.5)
L2—colonic15 (48.4)
L3—ileocolonic11 (35.5)
L4—upper disease1 (3.2)
J pouch2 (6.5)
Montreal classification—behaviour of the disease, n (%)
B1—non-stricturing, non-penetrating15 (48.4)
B2—stricturing3 (9.7)
B3—penetrating13 (41.9)
Previous history of perianal surgery19 (61.3)
Seton placement9 (29)
Fistulotomy4 (12.9)
Abscess drainage2 (6.5)
Fistulectomy2 (6.5)
Advancement flap1 (3.2)
Unknown1 (3.2)
Intestinal resection prior to induction13 (41.9)
Current seton at time of ustekinumab induction8 (25.8)
Concurrent immunomodulators at induction10 (32.6)
Previous use of immunomodulators
Azathioprine17 (54.8)
Methotrexate7 (22.6)
6-mercaptopurine6 (19.4)
Prior biological exposure
Infliximab25 (80.6)
Adalimumab25 (80.6)
Vedolizumab10 (32.3)
Certolizumab pegol6 (19.4)
Golimumab1 (3.2)