Table 1

Summary of included studies and patients’ characteristics

StudyTotal number of patients with IBD+COVID-19 (n)Study DesignCountryMean ageMale sex (n)Ulcerative colitis (n)Crohn’s disease (n)IBD undeterminedIBD drug
Allocca et al15ObservationalFrance and Italy39496NACorticosteroids, tacrolimus, everolimus, infliximab, vedolizumab, ustekinumab, adalimumab, mesalamine, azathioprine
Annapureddy et al464ObservationalUSA4826Not specifiedNot SpecifiedNABiologics
Attauabi et al76ObservationalDenmark52.5454531NA5-ASA, topical steroids
Axerlrad et al83ObservationalUSA35442756NACorticosteroids methotrexate, infliximab, vedolizumab, ustekinumab, adalimumab, mesalamine, azathioprine
Bezzio et al79ObservationalItaly45444732NACorticosteroids methotrexate, infliximab, vedolizumab, ustekinumab, adalimumab, mesalamine, azathioprine
Bezzio et al224ObservationalItaly45.979Not specifiedNot specifiedNABiologics
Burke et al39ObservationalUSA45.5152118NACorticosteroids, biologics, aminosalicylates, immunomodulators, tofacitinib
Calafat et al418ObservationalSpain7321829011711Immunomodulators
Conley et al203ObservationalUK426598105NACorticosteroids, biologics, immunomodulators
Derikx et al100ObservationalNetherlands62.5465936NACorticosteroids, biologics, 5-ASA, immunomodulators, tofacitinib
Gubatan et al5ObservationalUSA— California70.62320Corticosteroid, 5-ASA, 6MP/azathiprine, methotrexate, vedolizumab, ustekinumab, tofacitinib, anti-TNF
Kennedy et al590ObservationalUKNot specifiedNot specifiedNot specifiedNot specifiedNAInfliximab, vedolizumab
Khan et al649ObservationalUSA65Not specifiedNot specifiedNot specifiedNA5-ASA, prednisolone, thiopurine, biologics
Lamp et al211ObservationalUK59.511610986165-ASA, prednisolone, thiopurine, biologics
Lukin et al80ObservationalUSA—New York48.3452638NABiologics (anti-TNF, vedolizumab, ustekinumab), non biologics (tofacitinib), dual (vedolizumab +tofacitinib), 6MP, azathioprine, methotrexate, corticosteroids, 5-ASA
Meyer et al600ObservationalFrance50Not specifiedNot specifiedNot specifiedNABiologics, immunomodulators
Rizzello et al26ObservationalItalyNot specifiedNot specified1115NABiologics and 5-ASA
Rodríguez-Lago et al40ObservationalSpain5924231345-ASA
SECURE-IBD6438DatabaseMultiple countriesNot specified269925973539NACorticosteroids methotrexate, infliximab, vedolizumab, ustekinumab, adalimumab, 5-ASA, azathioprine, tofacitnib
Singh et al232ObservationalUSA51.2859310138Corticosteroids
Taxonera et al12ObservationalSpain52357NABiologics, 5-ASA, immunomodulators
Vadan et al7ObservationalItaly44.5543NACorticosteroids, biologics, immunomodulators