Table 3

Associations of hepatic fat content with subclinical vascular disease parameters in SHIP and KORA studies

NModel 1P valueModel 2P valueModel 3*P value
SHIP
Aortic diametersβ, 95% CIβ, 95% CIβ, 95% CI
 Ascending aorta (cm)12090.06 (0.04 to 0.08)<0.0010.01 (−0.02 to 0.03)0.4690.001 (−0.02 to 0.03)0.913
 Descending aorta (cm)12090.05 (0.04 to 0.07)<0.0010.01 (−0.01 to 0.02)0.2280.01 (−0.01 to 0.02)0.533
 Infrarenal aorta (cm)12090.02 (0.01 to 0.03)<0.001−0.01 (−0.02 to 0.01)0.282−0.001 (−0.01 to 0.01)0.837
Carotid plaqueOR, 95% CIOR, 95% CIOR, 95% CI
 Plaque presence13391.22 (1.05 to 1.42)0.0081.13 (0.95 to 1.33)0.1781.03 (0.85 to 1.25)0.753
β, 95% CIβ, 95% CIβ, 95% CI
 Carotid intima-media-thickness (mm)13390.01 (0.004 to 0.02)0.0020.002 (−0.01 to 0.01)0.538−0.003 (−0.01 to 0.004)0.401
KORA
Aortic diametersβ, 95% CIβ, 95% CIβ, 95% CI
 Ascending aorta (cm)3670.03 (−0.01 to 0.07)0.166−0.03 (−0.08 to 0.02)0.202−0.04 (−0.09 to 0.02)0.168
 Descending aorta (cm)3670.01 (−0.02 to 0.04)0.385−0.03 (−0.06 to 0.002)0.070−0.03 (−0.07 to 0.01)0.110
 Infrarenal aorta (cm)3670.02 (−0.004 to 0.03)0.115−0.01 (−0.03 to 0.02)0.536−0.01 (−0.04 to 0.01)0.349
Carotid plaqueOR, 95% CIOR, 95% CIOR, 95% CI
 Plaque presence2620.93 (0.66 to 1.32)0.6760.84 (0.56 to 1.25)0.3900.80 (0.49 to 1.29)0.354
 Plaque type2620.93 (0.66 to 1.31)0.6920.80 (0.53 to 1.20)0.2740.73 (0.45 to 1.19)0.206
β, 95% CIβ, 95% CIβ, 95% CI
 Wall thickness, LCA (mm)2510.01 (−0.01 to 0.03)0.474−0.01 (−0.03 to 0.01)0.186−0.02 (−0.04 to 0.01)0.179
 Wall thickness, RCA (mm)2570.01 (−0.01 to 0.02)0.534−0.01 (−0.03 to 0.01)0.193−0.01 (−0.03 to 0.01)0.287
 Lumen area, LCA (mm2)2550.02 (−0.03 to 0.06)0.481−0.01 (−0.06 to 0.05)0.8410.001 (−0.06 to 0.06)0.968
 Lumen area, RCA (mm2)2620.03 (−0.02 to 0.08)0.266−0.003 (−0.06 to 0.05)0.9150.04 (−0.03 to 0.10)0.271
 Wall area, LCA (mm2)2510.01 (−0.02 to 0.05)0.414−0.02 (−0.06 to 0.02)0.288−0.02 (−0.06 to 0.03)0.448
 Wall area, RCA (mm2)2570.02 (−0.01 to 0.06)0.173−0.01 (−0.05 to 0.03)0.537−0.01 (−0.04 to 0.05)0.827
 NWI, LCA2510.001 (−0.01 to 0.01)0.675−0.002 (−0.01 to 0.01)0.642−0.003 (−0.01 to 0.01)0.453
 NWI, RCA257−0.002 (−0.01 to 0.004)0.454−0.003 (-0.01 to 0.004)0.370−0.01 (−0.02 to–0.00003)0.061
  • Model 1: adjusted for age, sex.

  • Model 2: model 1+BMI

  • Model 3: model 2+smoking status, physical activity, alcohol intake, systolic blood pressure, HDL-C, LDL-C, triglycerides, glucose tolerance status, use of antihypertensive medication, use of lipid-lowering medication.

  • Results with p value<0.05 are shown in bold. The coefficient estimates represent the change in subclinical disease parameters with a SD increment of log-transformed hepatic fat content.

  • *Model 3 in SHIP was additionally adjusted for history of cardiovascular diseases.

  • β, β-estimates from linear regression; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; KORA, Cooperative Health Research in the Region of Augsburg; LCA, left carotid artery; LDL-C, low-density lipoprotein cholesterol; NWI, normalised wall index, calculated as wall area/(lumen area+wall area); RCA, right carotid artery; SHIP, Study of Health in Pomerania.