N | Model 1 | P value | Model 2 | P value | Model 3* | P value | |
SHIP | |||||||
Aortic diameters | β, 95% CI | β, 95% CI | β, 95% CI | ||||
Ascending aorta (cm) | 1209 | 0.06 (0.04 to 0.08) | <0.001 | 0.01 (−0.02 to 0.03) | 0.469 | 0.001 (−0.02 to 0.03) | 0.913 |
Descending aorta (cm) | 1209 | 0.05 (0.04 to 0.07) | <0.001 | 0.01 (−0.01 to 0.02) | 0.228 | 0.01 (−0.01 to 0.02) | 0.533 |
Infrarenal aorta (cm) | 1209 | 0.02 (0.01 to 0.03) | <0.001 | −0.01 (−0.02 to 0.01) | 0.282 | −0.001 (−0.01 to 0.01) | 0.837 |
Carotid plaque | OR, 95% CI | OR, 95% CI | OR, 95% CI | ||||
Plaque presence | 1339 | 1.22 (1.05 to 1.42) | 0.008 | 1.13 (0.95 to 1.33) | 0.178 | 1.03 (0.85 to 1.25) | 0.753 |
β, 95% CI | β, 95% CI | β, 95% CI | |||||
Carotid intima-media-thickness (mm) | 1339 | 0.01 (0.004 to 0.02) | 0.002 | 0.002 (−0.01 to 0.01) | 0.538 | −0.003 (−0.01 to 0.004) | 0.401 |
KORA | |||||||
Aortic diameters | β, 95% CI | β, 95% CI | β, 95% CI | ||||
Ascending aorta (cm) | 367 | 0.03 (−0.01 to 0.07) | 0.166 | −0.03 (−0.08 to 0.02) | 0.202 | −0.04 (−0.09 to 0.02) | 0.168 |
Descending aorta (cm) | 367 | 0.01 (−0.02 to 0.04) | 0.385 | −0.03 (−0.06 to 0.002) | 0.070 | −0.03 (−0.07 to 0.01) | 0.110 |
Infrarenal aorta (cm) | 367 | 0.02 (−0.004 to 0.03) | 0.115 | −0.01 (−0.03 to 0.02) | 0.536 | −0.01 (−0.04 to 0.01) | 0.349 |
Carotid plaque | OR, 95% CI | OR, 95% CI | OR, 95% CI | ||||
Plaque presence | 262 | 0.93 (0.66 to 1.32) | 0.676 | 0.84 (0.56 to 1.25) | 0.390 | 0.80 (0.49 to 1.29) | 0.354 |
Plaque type | 262 | 0.93 (0.66 to 1.31) | 0.692 | 0.80 (0.53 to 1.20) | 0.274 | 0.73 (0.45 to 1.19) | 0.206 |
β, 95% CI | β, 95% CI | β, 95% CI | |||||
Wall thickness, LCA (mm) | 251 | 0.01 (−0.01 to 0.03) | 0.474 | −0.01 (−0.03 to 0.01) | 0.186 | −0.02 (−0.04 to 0.01) | 0.179 |
Wall thickness, RCA (mm) | 257 | 0.01 (−0.01 to 0.02) | 0.534 | −0.01 (−0.03 to 0.01) | 0.193 | −0.01 (−0.03 to 0.01) | 0.287 |
Lumen area, LCA (mm2) | 255 | 0.02 (−0.03 to 0.06) | 0.481 | −0.01 (−0.06 to 0.05) | 0.841 | 0.001 (−0.06 to 0.06) | 0.968 |
Lumen area, RCA (mm2) | 262 | 0.03 (−0.02 to 0.08) | 0.266 | −0.003 (−0.06 to 0.05) | 0.915 | 0.04 (−0.03 to 0.10) | 0.271 |
Wall area, LCA (mm2) | 251 | 0.01 (−0.02 to 0.05) | 0.414 | −0.02 (−0.06 to 0.02) | 0.288 | −0.02 (−0.06 to 0.03) | 0.448 |
Wall area, RCA (mm2) | 257 | 0.02 (−0.01 to 0.06) | 0.173 | −0.01 (−0.05 to 0.03) | 0.537 | −0.01 (−0.04 to 0.05) | 0.827 |
NWI, LCA | 251 | 0.001 (−0.01 to 0.01) | 0.675 | −0.002 (−0.01 to 0.01) | 0.642 | −0.003 (−0.01 to 0.01) | 0.453 |
NWI, RCA | 257 | −0.002 (−0.01 to 0.004) | 0.454 | −0.003 (-0.01 to 0.004) | 0.370 | −0.01 (−0.02 to–0.00003) | 0.061 |
Model 1: adjusted for age, sex.
Model 2: model 1+BMI
Model 3: model 2+smoking status, physical activity, alcohol intake, systolic blood pressure, HDL-C, LDL-C, triglycerides, glucose tolerance status, use of antihypertensive medication, use of lipid-lowering medication.
Results with p value<0.05 are shown in bold. The coefficient estimates represent the change in subclinical disease parameters with a SD increment of log-transformed hepatic fat content.
*Model 3 in SHIP was additionally adjusted for history of cardiovascular diseases.
β, β-estimates from linear regression; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; KORA, Cooperative Health Research in the Region of Augsburg; LCA, left carotid artery; LDL-C, low-density lipoprotein cholesterol; NWI, normalised wall index, calculated as wall area/(lumen area+wall area); RCA, right carotid artery; SHIP, Study of Health in Pomerania.