Table 1

Clinical parameters

	Indication 1: variceal bleeding			Indication 2: refractory ascites
	TIPSS	Standard care	Source	TIPSS	Standard care	Source
Survival at 12 months	0.860	0.610	10	0.928*	0.553*	11
Survival at 24 months	0.860	0.610	10	0.890*	0.241*	11
TIPSS technical success	0.980	N/A	19	0.980	N/A	19
Shunt dysfunction	0.070	N/A	40	0.030	N/A	11
Variceal bleeding at 12 months	0.030	0.500	10	0.044†	0.182	21; 11
Variceal bleeding at 24 months	0.030	0.500	10	Assume same rates as 12 months
Ascites at 12 months	0.130	0.330	10	0.510	1.000	41
HE at 12 months	0.280	0.400	10	0.345	0.333	11
% HE severe‡	0.250	0.250	KOLs	0.400	0.636	11
SBP at 12 months	N/A	N/A	N/A	N/A	0.060	11
Catheter failure at 12 months	N/A	N/A	N/A	N/A	0.038§	20

*Survival rates for indication 2 were obtained by estimating parametric survival curves with a lognormal survival function, using 12-month patient data reported in Bureau et al. For further details, see online supplemental appendix 2).
†Conservative assumption applied as per economic evaluation of TIPSS for RA by Shen et al.21 The rate of variceal bleeding from Bureau et al is equal to 0% for TIPSS and 18.2% for standard care.11
‡Absolute % of severe HE calculated as overall HE rate multiplied by % HE severe. The remaining HE episodes are classified as mild. % of severe HE obtained from: KOL assumption for variceal bleeding; Bureau et al11 as number of OHE episodes grade >2/total number of OHE episodes.
§% with catheter failure at 12 months obtained by extrapolating value from source at 41 weeks (3%), assuming proportional rates between weeks 41 and 52.
HE, hepatic encephalopathy; KOL, key opinion leader; N/A, not applicable; RA, refractory ascites; SBP, spontaneous bacterial peritonitis; TIPSS, transjugular intrahepatic stent shunt.