Histological features of patients with cirrhosis compared between those with autoimmune hepatitis and those with other liver diseases
| Histological features | Autoimmune hepatitis | Other liver diseases (n=11) | P value* | ||
| All AIH (n=48) | Pure AIH (n=38) | AIH-PBC (n=10) | |||
| Interface hepatitis | <0.001 | ||||
| None | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 2 (18.1%) | |
| Mild | 9 (18.8%) | 7 (18.4%) | 2 (20%) | 6 (54.6%) | |
| Moderate to severe | 39 (81.2%) | 31 (81.6%) | 8 (80%) | 3 (27.3%) | |
| Emperipolesis | 7 (14.6%) | 6 (15.8%) | 1 (10%) | 0 (0.0%) | 0.329 |
| Rosette formation | 7 (14.6%) | 5 (13.2%) | 2 (20%) | 1 (9.1%) | 0.634 |
| Lymphocyte infiltration into the portal area | 0.007 | ||||
| None | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (9.1%) | |
| Mild | 29 (60.4%) | 23 (60.5%) | 6 (60%) | 10 (90.9%) | |
| Moderate to severe | 19 (39.6%) | 15 (39.5%) | 4 (40%) | 0 (0.0%) | |
| Plasma cell infiltration into the portal area | <0.001 | ||||
| None | 2 (4.2%) | 1 (2.6%) | 1 (10%) | 4 (36.4%) | |
| Mild | 25 (52.1%) | 21 (55.3%) | 4 (40%) | 7 (63.6%) | |
| Moderate to severe | 21 (43.7%) | 16 (42.1%) | 5 (50%) | 0 (0.0%) | |
| Lobular inflammation | 0.038 | ||||
| None | 7 (14.6%) | 5 (13.2%) | 2 (20%) | 4 (36.4%) | |
| Few | 18 (37.5%) | 14 (36.8%) | 4 (40%) | 5 (45.5%) | |
| Many | 23 (47.9%) | 19 (50%) | 4 (40%) | 2 (18.2%) | |
| Steatosis | 0.046 | ||||
| ≤5% | 39 (81.2%) | 30 (78.9%) | 9 (90%) | 5 (45.5%) | |
| >5%–33% | 7 (14.6%) | 6 (15.8%) | 1 (10%) | 5 (45.5%) | |
| >33%–66% | 2 (4.2%) | 2 (5.3%) | 0 (0.0%) | 1 (9.1%) | |
| Hepatocyte ballooning | 0.341 | ||||
| None | 23 (47.9%) | 16 (42.1%) | 7 (70%) | 3 (27.3%) | |
| Few | 16 (33.3%) | 15 (39.5%) | 1 (10%) | 4 (36.4%) | |
| Many | 9 (18.8%) | 7 (18.4%) | 2 (20%) | 4 (36.4%) | |
| Glycogenated nuclei | 11 (22.9%) | 11 (28.9%) | 0 (0.0%) | 5 (45.5%) | 0.133 |
| Mallory-Denk body | 14 (29.2%) | 12 (31.6%) | 2 (20%) | 8 (72.7%) | 0.008 |
| Florid duct lesion | 3 (6.3%) | 0 (0.0%) | 3 (30%) | 0 (0.0%) | 1.000 |
| Ductopenia | 7 (14.6%) | 1 (2.6%) | 6 (60%)† | 3 (27.3%) | 0.376 |
| Granuloma in portal area | 5 (10.4%) | 0 (0.0%) | 5 (50%)† | 0 (0.0%) | 0.572 |
Data presented as number and percentage
A p<0.05 indicates statistical significance
*Comparison between patients with all AIH and those with other liver diseases.
†A p<0.05 for comparison between patients with pure AIH and those with AIH-PBC.
AIH, autoimmune hepatitis; AIH-PBC, autoimmune hepatitis overlap with primary biliary cholangitis.