FAST score ≥4.5 | f-Hb ≥10 µg/g | Colon flag band 3 | f-Hb ≥10 µg/g and/or | |
ColonFlag band 3 | ||||
CRC | ||||
No of cases | 11 | 11 | 1 | |
True positives | 8 | 9 | 9 | 11 |
True negatives | 303 | 245 | 277 | 187 |
False positives | 73 | 132 | 100 | 190 |
False negatives | 3 | 2 | 2 | 0 |
Sensitivity | 72.7 (39.0–94.0) | 81.8 (48.2–97.7) | 81.8 (48.2–97.7) | 100 (71.5–100) |
Specificity | 80.6 (76.2–84.5) | 64.9 (59.9–69.8) | 73.5 (68.7–77.9) | 49.6 (44.4–54.8) |
PPV | 9.9 (6.7–14.3) | 6.4 (4.8–8.5) | 8.3 (6.1–11.1) | 5.5 (4.9–6.0) |
NPV | 99.0 (97.5–99.6) | 99.2 (97.2–99.8) | 99.3 (97.6–99.8) | 100 |
CRC+HRA | ||||
No of cases | 35 | 35 | 35 | 35 |
True positives | 21 | 25 | 15 | 30 |
True negatives | 293 | 237 | 259 | 182 |
False positives | 60 | 116 | 94 | 171 |
False negatives | 14 | 10 | 20 | 5 |
Sensitivity | 60.0 (42.1–76.1) | 71.4 (53.7–85.4) | 42.9 (26.3–60.7) | 85.7 (69.7–95.2) |
Specificity | 83.0 (78.7–86.8) | 67.3 (62.2–72.2) | 73.4 (68.4–77.9) | 51.6 (46.2–56.9) |
PPV | 25.9 (19.70–33.3) | 17.9 (14.4–21.0) | 13.7 (9.5–19.5) | 14.9 (12.9–17.3) |
NPV | 95.4 (93.3–96.9) | 95.6 (93.3–97.6) | 92.8 (90.6–−94.6) | 97.3 (94.1–98.8) |
CRC+HRA+IBD | ||||
No of cases | 43 | 43 | 43 | 43 |
True positives | 29 | 33 | 17 | 38 |
True negatives | 293 | 237 | 253 | 182 |
False positives | 52 | 108 | 92 | 163 |
False negatives | 14 | 10 | 26 | 5 |
Sensitivity | 67.4 (51.5–80.9) | 76.7 (61.4–88.2) | 39.5 (25.0–55.6) | 88.4 (74.9–96.1) |
Specificity | 84.9 (80.7–88.5) | 68.7 (63.5–73.6) | 73.3 (68.3–78.0) | 52.8 (47.3–58.1) |
PPV | 35.8 (28.7–43.6) | 23.4 (19.6–27.7) | 15.6 (10.9–21.8) | 18.9 (16.64–21.4) |
NPV | 95.4 (93.1–97.0) | 96.0 (93.2–97.6) | 69.6 (64.7–74.1) | 97.3 (94.1–98.8) |
CRC, colorectal cancer; f-HB, faecal haemoglobin; HRA, high risk adenomas; IBD, inflammatory bowel disease; NPV, negative predictive value; PPV, positive predictive value.