Baseline characteristics of ulcerative colitis patients by tricyclic antidepressant exposure status
| TCA non-users* n=6064 | TCA intermittent users* n=246 | TCA continuous users* n=63 | |
| Male sex | 3351 (55%) | 112 (46%) | 26 (41%) |
| Age at diagnosis | |||
| <17 years | 197 (3%) | 0 (0%) | 1 (2%) |
| 17–40 years | 1778 (29%) | 77 (31%) | 14 (22%) |
| >40 years | 4089 (67%) | 169 (69%) | 48 (76%) |
| Era of diagnosis | |||
| 2005–2008 | 2970 (46%) | 112 (46%) | 33 (52%) |
| 2009–2012 | 2379 (39%) | 98 (40%) | 22 (35%) |
| 2013–2016 | 895 (15%) | 36 (15%) | 8 (13%) |
| Smoker | 517 (9%) | 28 (11%) | 7 (11%) |
| SSRI use | |||
| Non-users | 5230 (86%) | 190 (77%) | 44 (70%) |
| Intermittent users | 566 (9%) | 50 (20%) | 11 (17%) |
| Continuous users | 268 (4%) | 6 (2%) | 8 (13%) |
*Non-users defined as patients with no TCA prescriptions in first 3 years of diagnosis.
†Intermittent users defined as patients who received at least one TCA prescriptions within the first 3 years of diagnosis but were not continuous users.
‡Continuous users defined as patients with consecutive TCA prescriptions for first 3 years after diagnosis where the interval between TCA prescription <90 days.
SSRI, serotonin selective reuptake inhibitor; TCA, tricyclic antidepressant.