Table 2

Histological and immunohistochemical characteristics

Case no.	Fibrosis	Distribution of macrophages	Density of histiocytes	Cytoplasm of macrophages	Nuclei of macrophages	Giant cells	Phenotype
1	No	Superficial	Low	Foamy	Fine chromatin, nucleolated	Yes	S100^–, CD163⁺, CD1a^–, pERK⁺
2	No	Superficial	Low	Eosinophil	Heterogenous	Yes	S100^–, CD163⁺, CD68⁺, CD1a^–, pERK⁺
3	Yes	Superficial and deep	Moderate	Foamy	Small dense	No	S100^–, CD163⁺, CD68⁺, CD1a^–, pERK^–
4	No	Superficial and deep	Moderate	Foamy	Small dense	No	S100^–, CD163⁺, CD1a^–, pERK^–
5	No	Superficial	High	Foamy	Small dense	No	CD163⁺, CD68⁺, CD1a^–, pERK^–
6	No	Superficial and deep	High	Eosinophil	Small dense, folded	Yes	S100^–, CD68⁺, CD1a^–, pERK⁺
7	No	Superficial and deep	Low	Foamy+eosinophil	Small dense	Yes	S100^–, CD68⁺, CD1a^–
8	No	Superficial	High	Foamy	Small dense	No	S100^–, CD163⁺, CD68⁺,CD1a^–
9	No	Superficial	Low	Eosinophil	Heterogenous	Yes	S100⁺, CD163⁺, CD1a^–, pERK⁺
10	Yes	Superficial and deep	Moderate	Foamy	Heterogenous	Yes	S100^–, CD68⁺, CD1a^–
11	Yes	NA (small sample)	Low	Foamy+eosinophil	Fine chromatin, nucleolated	No	CD163⁺, CD1a^–
12	No	Superficial and deep	High	Foamy	Small dense	No	CD163⁺, CD68⁺, CD1a^–
13	No	Superficial and deep	High	Foamy	Pleomorphic	Yes	S100^–, CD163⁺, CD68⁺, CD1a^–, pERK^–
14	No	Deep	Moderate	Foamy	Fine chromatin, nucleolated	Non	S100⁺, CD163⁺, CD68⁺, CD1a^–, pERK⁺
15	No	Superficial	Low	Foamy+eosinophil	Heterogenous	Yes	S100^–, CD163⁺, CD1a^–, pERK^–
16	No*	Superficial and deep	High	Foamy+eosinophil	Heterogenous	No	S100^–, CD163⁺, CD1a^–, pERK⁺
17	Yes	NA (small sample)	High	Foamy	Small dense	No	S100^–, CD163⁺, CD68⁺, CD1a^–
18	Yes	Deep	Low	Eosinophil	Fine chromatin, nucleolated	Yes	S100⁺, CD163⁺, CD68⁺, CD1a^–, pERK⁺
19	Yes	Deep	Moderate	Foamy+eosinophil	Fine chromatin, nucleolated	Yes	S100^–, CD68⁺, CD1a^–
20	No	Deep	High	Foamy	Heterogenous	No	S100^–, CD163⁺, CD68⁺, CD1a^–, pERK⁺
21	Yes	Superficial and deep	Moderate	Foamy+eosinophil	Heterogenous	No	S100^–, CD163⁺, CD68⁺, CD1a^–, pERK⁺
22	No	Superficial and deep	Moderate	Foamy+eosinophil	Heterogenous	Yes	S100⁺, CD163⁺, CD68⁺, CD1a^–, pERK⁺

*Cytosteatonecrosis associated.
NA, not analysable.